Product image of Novaminsulfon Lichtenstein (Metamizole Sodium Monohydrate) supplied by GNH India

Novaminsulfon Lichtenstein

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Novaminsulfon Lichtenstein (Metamizole Sodium Monohydrate)

Metamizole Sodium, the active ingredient in Novaminsulfon Lichtenstein, is a non‑opioid analgesic (pyrazolone) presented as a rectal formulation for rectal use. It is employed to relieve moderate to severe pain and to reduce fever in adult patients.
GNH India supplies Novaminsulfon Lichtenstein as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Winthrop Arzneimittel Gmbh

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Indications & Clinical Uses

Metamizole Sodium is a non‑opioid analgesic used for pain and fever management.

  • Pain relief: provides effective analgesia for moderate to severe acute pain.
  • Fever reduction: lowers elevated body temperature in febrile conditions.
  • Post‑operative pain: helps control pain following surgical procedures.
  • Cancer‑related pain: may be incorporated into multimodal analgesic regimens for oncologic patients.
  • Acute musculoskeletal pain: alleviates discomfort from injuries or strain.

How It Works

  • Metamizole Sodium exerts its effect through non‑selective inhibition of cyclooxygenase enzymes, which reduces prostaglandin synthesis. The decreased prostaglandin levels diminish peripheral nociceptor sensitisation and central pain transmission. Additionally, the compound possesses spasmolytic activity that contributes to its analgesic and antipyretic properties.

Side Effects

Metamizole Sodium may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional emesis following administration.
  • Dizziness: transient light‑headedness or vertigo.
  • Hypotension: temporary drop in blood pressure.
  • Skin rash: mild erythematous reactions.
  • Elevated liver enzymes: transient increase in hepatic markers.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells, requiring immediate medical attention.
  • Anaphylaxis: life‑threatening allergic reaction with airway compromise.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.
  • Toxic epidermal necrolysis: extensive skin detachment and systemic involvement.
  • Blood dyscrasias: abnormal blood cell counts beyond agranulocytosis.
  • Severe hypotension: profound circulatory collapse.

Precautions & Warnings

When prescribing Metamizole Sodium, clinicians should observe several safety measures.

  • Baseline blood count: obtain complete blood count before initiating therapy.
  • Monitor for infection: watch for signs of neutropenia or infection during treatment.
  • Hepatic impairment: use cautiously in patients with liver disease.
  • Known hypersensitivity: avoid in individuals with documented allergy to pyrazolones.
  • Renal dysfunction: adjust use in patients with compromised kidney function.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metamizole Sodium can interact with other medicines, necessitating careful review.

Major Interactions (Avoid)

  • Anticoagulants: increased risk of bleeding.
  • Other NSAIDs: heightened gastrointestinal toxicity.
  • Allopurinol: elevated risk of agranulocytosis.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: potential for reduced renal function.
  • Diuretics: may enhance hypotensive effects.
  • Lithium: possible increase in lithium serum levels.

Frequently Asked Questions

Novaminsulfon Lichtenstein contains Metamizole Sodium, which is employed to relieve moderate to severe pain and to reduce fever. It is commonly used in acute pain settings, postoperative care, and febrile conditions where a non‑opioid analgesic is appropriate.

Metamizole Sodium works by non‑selectively inhibiting cyclooxygenase enzymes, leading to reduced prostaglandin synthesis. This action diminishes peripheral nociceptor sensitisation and central pain signalling, while also providing spasmolytic effects that contribute to its analgesic and antipyretic properties.

The exact dosage of Novaminsulfon Lichtenstein is determined by the prescribing clinician based on the patient’s condition, age, weight, and renal or hepatic function. Healthcare professionals should follow local guidelines and adjust the dose as needed for individual patients.

Safety data for Metamizole Sodium in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider after careful assessment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metamizole Sodium is a non‑opioid analgesic that offers strong pain relief and antipyretic effects, often considered when NSAIDs are contraindicated or insufficient. Unlike opioids, it does not cause respiratory depression, but it carries a risk of agranulocytosis, which is less common with many other analgesics.

Novaminsulfon Lichtenstein should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain its stability and efficacy.

The product is formulated for rectal administration. It is typically inserted into the rectum using the supplied applicator or as directed by a healthcare professional, ensuring proper placement for optimal absorption.

The most serious adverse reactions include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe hypersensitivity reactions such as anaphylaxis, Stevens‑Johnson syndrome, or toxic epidermal necrolysis. Immediate medical attention is required if any of these symptoms appear.

Patients with known hypersensitivity to Metamizole Sodium or other pyrazolones, those with a history of agranulocytosis, and individuals with severe hepatic or renal impairment should avoid using this medication unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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