Product image of Novaminsulfon-Ratiopharm (Metamizole Sodium Monohydrate) supplied by GNH India

Novaminsulfon-Ratiopharm

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Novaminsulfon-Ratiopharm (Metamizole Sodium Monohydrate)

Metamizole sodium, the active ingredient in Novaminsulfon‑Ratiopharm, is a pyrazolone non‑opioid analgesic presented as a sterile solution for intramuscular and intravenous use. It is employed to relieve moderate to severe pain and to reduce fever in adult patients.
GNH India supplies Novaminsulfon‑Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Novaminsulfon‑Ratiopharm, a non‑opioid analgesic, is used in conditions where pain or fever require rapid control.

  • Pain relief: provides effective analgesia for acute postoperative or traumatic pain.
  • Fever reduction: lowers elevated body temperature in febrile states.
  • Post‑operative analgesia: supports pain management after surgical procedures.
  • Colic: alleviates severe abdominal pain associated with colic syndromes.

How It Works

  • Metamizole sodium inhibits cyclooxygenase enzymes, leading to reduced synthesis of prostaglandins that mediate pain and fever. While the exact pathway is not fully defined, the drug’s action on central and peripheral prostaglandin pathways contributes to its analgesic and antipyretic effects without engaging opioid receptors.

Side Effects

Metamizole sodium may cause a range of adverse reactions. Monitoring patients for any signs of side effects is essential.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Dizziness: transient light‑headedness.
  • Hypotension: occasional drop in blood pressure after injection.
  • Injection site pain: local discomfort at the administration site.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells, potentially life‑threatening.
  • Anaphylactic reaction: rapid onset of allergic symptoms requiring emergency care.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Blood dyscrasias: rare hematologic abnormalities such as thrombocytopenia.

Precautions & Warnings

Before using Novaminsulfon‑Ratiopharm, clinicians should consider several safety measures.

  • Renal function assessment: adjust use in patients with impaired kidney function.
  • Blood count monitoring: regular hematologic checks to detect agranulocytosis early.
  • Hypersensitivity screening: avoid in individuals with known allergy to metamizole or related compounds.
  • Elderly caution: start with the lowest effective dose and monitor closely.
  • Concomitant NSAIDs: limit combined use to reduce risk of gastrointestinal and renal adverse effects.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metamizole sodium can interact with other medicines, influencing safety and efficacy.

Major Interactions (Avoid)

  • Myelosuppressive agents: concurrent use may markedly increase risk of severe blood dyscrasias.
  • Warfarin: potentiates anticoagulant effect, raising bleeding risk.

Moderate Interactions (Monitor Closely)

  • NSAIDs: additive gastrointestinal irritation and renal impairment.
  • Corticosteroids: heightened susceptibility to infection.
  • Alcohol: may enhance hypotensive response.
  • ACE inhibitors: possible reduction in antihypertensive effect.

Frequently Asked Questions

Novaminsulfon‑Ratiopharm contains metamizole sodium, a non‑opioid analgesic used to treat moderate to severe pain, reduce high fever, and provide postoperative pain control. It is also employed in managing colic‑related abdominal pain in adult patients.

Metamizole sodium works by inhibiting cyclooxygenase enzymes, which lowers the production of prostaglandins—substances that trigger pain and fever. This reduction in prostaglandin levels leads to its analgesic and antipyretic effects, while its exact central mechanisms remain partially understood.

The appropriate dose of Novaminsulfon‑Ratiopharm is determined by the prescribing clinician based on the patient’s condition, age, weight, and renal function. Healthcare professionals set the dosage and administration schedule according to current medical guidelines.

Safety data for metamizole sodium in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with opioid analgesics, metamizole offers effective pain relief without the risk of respiratory depression or dependence. Unlike many NSAIDs, it has a lower incidence of gastrointestinal ulceration but carries a rare risk of agranulocytosis, which requires regular blood monitoring.

Novaminsulfon‑Ratiopharm should be stored at ambient temperature, below 25 °C, in its original container. Protect the product from moisture, direct sunlight and extreme temperature fluctuations to maintain its stability and sterility.

The medication is supplied as a sterile solution for intramuscular or intravenous injection. Administration is performed by a qualified healthcare professional, who selects the appropriate route, dose and injection site based on the clinical indication.

The most serious risks include agranulocytosis, a potentially fatal drop in white blood cells, and severe allergic reactions such as anaphylaxis. Patients should be monitored for signs of infection, fever, or allergic symptoms, and immediate medical attention is required if they occur.

Novaminsulfon‑Ratiopharm is contraindicated in individuals with known hypersensitivity to metamizole or any pyrazolone derivatives, in patients with a history of agranulocytosis, and in those for whom the risk of severe blood dyscrasias outweighs the therapeutic benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Metamizole Sodium Monohydrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT