Product image of Novistig (Glycopyrronium Bromide, Neostigmine Methylsulfate) supplied by GNH India

Novistig

Active Ingredient:
Glycopyrronium Bromide, Neostigmine Methylsulfate
Origin:
EU

Novistig (Glycopyrronium Bromide, Neostigmine Methylsulfate)

Glycopyrronium bromide and neostigmine methylsulfate, the active ingredients in Novistig, are a muscarinic antagonist and an acetylcholinesterase inhibitor presented as an intravenous solution for peri‑operative use. It is used to reverse non‑depolarising neuromuscular blockade and to control secretions in adult surgical patients.

GNH India supplies Novistig as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Sintetica Gmbh

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Indications & Clinical Uses

Novistig combines a muscarinic antagonist with an acetylcholinesterase inhibitor to act on the cholinergic pathway during surgery.

  • Reversal of non‑depolarising neuromuscular blockade: restores muscle strength after anesthesia.
  • Control of peri‑operative secretions: reduces salivary and respiratory secretions to improve airway management.
  • Prevention of postoperative bradycardia: mitigates vagally mediated heart‑rate slowing after cholinesterase inhibition.

How It Works

  • Glycopyrronium bromide blocks peripheral muscarinic acetylcholine receptors, decreasing glandular secretions and counteracting bradycardia, while neostigmine methylsulfate inhibits acetylcholinesterase, raising acetylcholine levels at the neuromuscular junction to enhance transmission and reverse muscle relaxation caused by non‑depolarising blockers.

Side Effects

Novistig may cause a range of adverse reactions.

Common Side Effects

  • Dry mouth
  • Tachycardia
  • Nausea
  • Abdominal discomfort
  • Urinary retention
  • Headache

Serious or Rare Side Effects

  • Bronchospasm
  • Severe bradycardia or arrhythmia
  • Anaphylactic reaction
  • Prolonged neuromuscular blockade
  • Seizures

Precautions & Warnings

Use Novistig with appropriate clinical monitoring.

  • Assess renal and hepatic function: adjust use in impairment.
  • Monitor heart rate and blood pressure: watch for bradycardia or tachyarrhythmia.
  • Avoid in patients with known hypersensitivity to either component.
  • Use caution in asthma or COPD: risk of bronchospasm.
  • Adjust dosing in elderly patients: increased sensitivity.
  • Store at ambient temperature: keep in original pack, protect from moisture and light.

Avoid Interactions

Novistig can interact with several drug classes.

Major Interactions (Avoid)

  • Other anticholinergic agents: additive anticholinergic burden.
  • Beta‑blockers: may exacerbate bradycardia when combined with cholinesterase inhibition.
  • Potassium channel blockers: increased risk of arrhythmia.

Moderate Interactions (Monitor Closely)

  • Anesthetic agents: may potentiate cardiovascular effects.
  • Diuretics: electrolyte shifts can affect neuromuscular transmission.
  • Aminoglycoside antibiotics: may enhance residual neuromuscular blockade.

Frequently Asked Questions

Novistig is a prescription injectable that combines glycopyrronium bromide, a muscarinic antagonist, with neostigmine methylsulfate, an acetylcholinesterase inhibitor. The combination is employed in peri‑operative settings to reverse non‑depolarising neuromuscular blockade and to reduce airway and salivary secretions after surgery.

Glycopyrronium bromide blocks muscarinic acetylcholine receptors in the peripheral nervous system, decreasing secretions from salivary and respiratory glands and counteracting bradycardia that can be induced by cholinesterase inhibition. Its quaternary structure limits central nervous system penetration, providing a peripheral anticholinergic effect.

Neostigmine methylsulfate inhibits acetylcholinesterase, the enzyme that degrades acetylcholine at the neuromuscular junction. By raising acetylcholine concentrations, it enhances transmission at nicotinic receptors, thereby restoring muscle tone and facilitating reversal of neuromuscular blocking agents used during anesthesia.

The dose of Novistig is determined by the prescribing clinician based on the patient’s weight, the type and extent of neuromuscular blockade, and intra‑operative monitoring. Dosage adjustments are made according to standard clinical guidelines and the specific surgical context.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and the necessary

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GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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