Product image of Novistig (Glycopyrronium Bromide, Neostigmine Methylsulfate) supplied by GNH India

Novistig

Active Ingredient:
Glycopyrronium Bromide, Neostigmine Methylsulfate
Origin:
EU

Novistig (Glycopyrronium Bromide, Neostigmine Methylsulfate)

Glycopyrronium bromide and Neostigmine methylsulfate, the active ingredients in Novistig, are an anticholinergic muscarinic antagonist and an acetylcholinesterase inhibitor presented for intravenous use. They are employed to relieve bronchospasm in chronic obstructive pulmonary disease or asthma and to reverse non‑depolarizing neuromuscular blockade after surgery.

GNH India supplies Novistig as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Sintetica Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Novistig acts on the respiratory and neuromuscular systems to manage acute and chronic airway constriction and to restore muscle function after surgery.

  • Bronchospasm associated with COPD or asthma: provides bronchodilation and reduces airway secretions.
  • Reversal of neuromuscular blockade after surgery: restores muscle strength by increasing acetylcholine at the neuromuscular junction.
  • Acute bronchospasm: delivers rapid relief of airway constriction during emergency episodes.

How It Works

  • Glycopyrronium bromide competitively blocks muscarinic acetylcholine receptors in airway smooth muscle, leading to bronchodilation and decreased secretions. Neostigmine methylsulfate inhibits acetylcholinesterase, raising acetylcholine levels at neuromuscular junctions, thereby overcoming the effects of non‑depolarizing neuromuscular blocking agents and restoring muscle contraction.

Side Effects

Novistig may cause a range of adverse reactions, from mild to severe, depending on patient sensitivity and clinical context.

Common Side Effects

  • Dry mouth: reduced salivary secretion.
  • Urinary retention: difficulty initiating urination.
  • Tachycardia: increased heart rate.
  • Headache: mild to moderate intensity.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Cardiac arrhythmia: irregular heart rhythm that may be life‑threatening.
  • Prolonged neuromuscular blockade: persistent muscle weakness after surgery.

Precautions & Warnings

Before administering Novistig, clinicians should consider several safety measures.

  • Cardiac monitoring: observe for tachycardia or arrhythmias.
  • Urinary assessment: evaluate for pre‑existing retention or obstruction.
  • Glaucoma caution: avoid in patients with narrow‑angle glaucoma.
  • Renal function: adjust use in severe renal impairment.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Novistig can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Non‑depolarizing neuromuscular blockers: may reduce reversal effectiveness.
  • Anticholinergic agents: can increase risk of dry mouth and urinary retention.

Moderate Interactions (Monitor Closely)

  • Beta‑agonists: additive bronchodilatory effect may cause tachycardia.
  • Renally excreted drugs (e.g., aminoglycosides): may require dose adjustment.
  • Certain antihypertensives: potential for additive cardiovascular effects.

Frequently Asked Questions

Novistig is indicated for the treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD) or asthma, and for the reversal of non‑depolarizing neuromuscular blockade following surgical procedures. It helps open the airways and restore muscle function after anesthesia.

Glycopyrronium bromide blocks muscarinic acetylcholine receptors in airway smooth muscle, preventing bronchoconstriction and reducing secretions. This anticholinergic action leads to bronchodilation, improving airflow in patients with obstructive lung disease.

The dosage of Novistig is determined by the prescribing clinician based on the patient’s condition, weight, and response. It is administered intravenously under medical supervision, and the exact regimen should follow the healthcare professional’s instructions.

The safety of Novistig in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Novistig combines an anticholinergic (glycopyrronium) with an acetylcholinesterase inhibitor (neostigmine), offering both bronchodilation and neuromuscular blockade reversal. Unlike pure β2‑agonists, it does not rely on adrenergic pathways, which can reduce the risk of tachycardia but may increase anticholinergic side effects.

Novistig should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct sunlight to maintain stability.

Novistig is given by intravenous injection or infusion under the supervision of qualified medical personnel. The route ensures rapid onset of action for both bronchodilation and reversal of neuromuscular blockade.

Serious risks include anaphylactic reactions, cardiac arrhythmias, and prolonged neuromuscular blockade. Patients should be monitored closely for signs of allergic response, heart rhythm changes, and persistent muscle weakness after administration.

Novistig is contraindicated in patients with known hypersensitivity to glycopyrronium bromide, neostigmine methylsulfate, or any excipients. Caution is advised in individuals with narrow‑angle glaucoma, severe urinary retention, or uncontrolled cardiac disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Glycopyrronium Bromide, Neostigmine Methylsulfate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT