Product image of Noxap (Nitric Oxide) supplied by GNH India

Noxap

Active Ingredient:
Nitric Oxide
Origin:
EU

Noxap (Nitric Oxide)

Nitric Oxide, the active ingredient in Noxap, is a pulmonary vasodilator presented as a gas for inhalation use. It is used to manage pulmonary hypertension and related vascular conditions in adult patients. GNH India supplies Noxap as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

GNH India supplies Noxap as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Air Products Gmbh

1
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Indications & Clinical Uses

Noxap is a pulmonary vasodilator that acts on the pulmonary arterial circulation to lower pressure and improve oxygenation.

  • Pulmonary arterial hypertension: helps reduce pulmonary artery pressure and improve exercise capacity.
  • Acute right‑heart strain: supports right‑ventricular function by lowering afterload.
  • Post‑cardiac surgery pulmonary hypertension: aids in stabilising haemodynamics after operative procedures.

How It Works

  • Nitric oxide delivered by inhalation diffuses into the pulmonary vasculature where it activates soluble guanylate cyclase in smooth‑muscle cells. This increases cyclic GMP levels, causing relaxation of pulmonary arterial smooth muscle and resulting in selective vasodilation of the ventilated lung regions, thereby improving ventilation‑perfusion matching and reducing pulmonary arterial pressure.

Side Effects

Adverse reactions to inhaled nitric oxide are generally related to its vasodilatory action and the delivery system.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Flushing: warmth and reddening of the skin, typically short‑lived.
  • Cough: irritation of the airway during inhalation.
  • Methemoglobinemia methemoglobinemia: elevated 
  • Nausea:
  • Dizziness:

Serious or Rare Side Effects

  • Severe hypotension: marked drop in systemic blood pressure.
  • Rebound pulmonary hypertension: rapid increase in pulmonary pressure after abrupt discontinuation.
  • Bleeding :
  • Toxic 

g 

  • Toxic  .

Precautions & Warnings

  • Noxap should be only  
  • g 
  • t  ​  
  • ewline  
  • ewline ​   
  • -  
  • ewline 
  • ewline 
  • ewline

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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