Product image of Noxphyr (Nitric Oxide) supplied by GNH India

Noxphyr

Active Ingredient:
Nitric Oxide
Origin:
EU

Noxphyr (Nitric Oxide)

Nitric Oxide, the active ingredient in Noxphyr, is a gaseous signaling molecule presented as an inhalation formulation for respiratory use. It is investigated for its potential to modulate vascular tone and improve oxygenation in specific clinical settings.
GNH India supplies Noxphyr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sol Spa

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Indications & Clinical Uses

Noxphyr contains nitric oxide, a molecule studied for its role in pulmonary vascular regulation and oxygen delivery.

  • Pulmonary hypertension (investigational): may help lower pulmonary arterial pressure in acute settings.
  • Neonatal respiratory distress (research): explored to improve oxygenation in preterm infants with persistent pulmonary hypertension.
  • Acute respiratory failure (clinical trial): evaluated for transient improvement of gas exchange during severe hypoxemia.

How It Works

  • Nitric oxide acts as an endogenous vasodilator by stimulating soluble guanylate cyclase in smooth muscle cells, increasing cyclic GMP levels and leading to relaxation of vascular smooth muscle. In the pulmonary circulation, this results in selective dilation of ventilated lung regions, enhancing ventilation‑perfusion matching and improving arterial oxygenation.

Side Effects

Inhaled nitric oxide can produce a range of adverse reactions, most of which are dose‑related and reversible upon discontinuation.

Common Side Effects

  • Headache: mild to moderate, often transient.
  • Dizziness: related to systemic vasodilation.
  • Nausea: occasional, generally mild.
  • Flushing: skin warmth and redness.
  • Cough: irritation of the airway.

Serious or Rare Side Effects

  • Methemoglobinemia: elevated methemoglobin levels reducing oxygen delivery.
  • Hypotension: systemic blood pressure drop in sensitive individuals.
  • Bleeding: increased risk in patients receiving anticoagulants.
  • Rebound pulmonary hypertension: worsening pressure after abrupt discontinuation.
  • Respiratory infection: potential colonisation of delivery system.

Precautions & Warnings

When considering Noxphyr, clinicians should evaluate patient‑specific factors and follow safe handling practices.

  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Breastfeeding: unknown excretion; caution advised.
  • Renal impairment: monitor because of altered nitric oxide metabolism.
  • Hemoglobin disorders: assess methemoglobin levels regularly.
  • Concomitant vasodilators: watch for additive hypotensive effects.
  • Store at ambient temperature: keep container tightly closed, protect from moisture and direct sunlight.

Avoid Interactions

Nitric oxide can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors: may cause profound hypotension.
  • Inhaled anesthetics (e.g., nitrous oxide): can increase methemoglobin formation.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: heightened bleeding risk.
  • Antihypertensives: additive blood pressure lowering.
  • Hemoglobin‑oxidizing agents: potential for increased methemoglobinemia.

Frequently Asked Questions

Noxphyr is an inhaled formulation of nitric oxide that is being studied for its ability to improve pulmonary vascular tone and oxygenation in conditions such as acute pulmonary hypertension, neonatal respiratory distress, and severe respiratory failure. It is not yet approved for routine clinical use.

Nitric oxide activates soluble guanylate cyclase in vascular smooth muscle, raising cyclic GMP levels. This cascade leads to selective relaxation of pulmonary vessels, improving ventilation‑perfusion matching and enhancing arterial oxygen levels.

The dosing regimen for Noxphyr is determined by the prescribing clinician based on the specific clinical scenario, patient weight, and response. No fixed dose can be provided without a medical prescription.

Safety data for Noxphyr in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and import documentation.

Noxphyr delivers nitric oxide directly to the lungs, offering selective pulmonary vasodilation with minimal systemic effects, whereas oral or intravenous agents such as phosphodiesterase‑5 inhibitors affect the entire circulatory system and may cause broader hypotension.

Store Noxphyr at ambient temperature, keeping the container tightly sealed, protected from moisture and direct sunlight. Do not expose the product to extreme temperatures or humidity to maintain its stability.

Noxphyr is administered by inhalation through a calibrated delivery system that mixes the nitric oxide gas with the patient’s breathing circuit. Administration is performed by trained healthcare personnel in a monitored setting.

Serious risks include methemoglobinemia, which reduces oxygen-carrying capacity, and rebound pulmonary hypertension that can occur if therapy is stopped abruptly. Monitoring of methemoglobin levels and gradual weaning are essential to mitigate these risks.

Patients with known hypersensitivity to nitric oxide, those with severe methemoglobinemia, or individuals receiving high‑dose phosphodiesterase‑5 inhibitors should avoid Noxphyr. Clinical judgment is required for patients with unstable hemodynamics or significant bleeding disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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