Product image of Nozac (Nebivolol Hydrochloride) supplied by GNH India

Nozac

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nozac (Nebivolol Hydrochloride)

Nebivolol Hydrochloride, the active ingredient in Nozac, is a beta blocker presented as an oral formulation for oral use. It is prescribed to lower elevated blood pressure in adult patients with hypertension. The drug combines selective β1‑adrenergic antagonism with nitric‑oxide‑mediated vasodilation, providing effective blood pressure control.

GNH India supplies Nozac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality manufacturing, regulatory compliance, and reliable logistics for global distribution.

Manufacturer / TM Owner

Pharmazac Sa

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Indications & Clinical Uses

  • Nebivolol is used in the management of cardiovascular conditions, primarily hypertension.
  • Hypertension: reduces systolic and diastolic blood pressure by decreasing heart rate and promoting vasodilation.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, diminishing sympathetic stimulation of the heart, which lowers heart rate and contractility. In addition, it enhances endothelial nitric‑oxide release, causing smooth‑muscle relaxation and vasodilation. The combined β1‑blockade and nitric‑oxide‑mediated vasodilatory effect leads to a reduction in systemic vascular resistance and arterial pressure.

Side Effects

Nebivolol may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild to moderate pain often occurring early in therapy.
  • Dizziness: sensation of light‑headedness, especially when standing quickly.
  • Fatigue: general tiredness or reduced energy levels.
  • Nausea: upset stomach or urge to vomit.

Serious or Rare Side Effects

  • Severe bradycardia: markedly slow heart rate that may require medical attention.
  • Hypotension: significant drop in blood pressure leading to fainting or shock.
  • Allergic reactions: rash, itching, swelling, or rare anaphylaxis.

Precautions & Warnings

  • When prescribing Nebivolol, several safety considerations should be observed.
  • Blood pressure monitoring: check BP regularly after initiation and dose changes.
  • Discontinuation: avoid abrupt cessation to prevent rebound hypertension.
  • Liver impairment: use caution and consider dose adjustment in severe hepatic dysfunction.
  • Asthma or chronic obstructive pulmonary disease: monitor for bronchospasm as β1‑selectivity may not fully protect.
  • Concomitant beta‑blockers: avoid combined use to prevent excessive cardiac depression.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture and light.

Avoid Interactions

Nebivolol can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Other β‑blockers: additive cardiac depression.
  • Calcium channel blockers verapamil or diltiazem: increased risk of bradycardia and AV block.
  • Strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine): raise nebivolol plasma levels.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs: may reduce antihypertensive effect.
  • Diuretics: can potentiate hypotensive response, monitor electrolytes.
  • Other antihypertensives (ACE inhibitors, ARBs): may cause additive blood pressure lowering.

Frequently Asked Questions

Nozac contains nebivolol hydrochloride, a beta‑blocker indicated for the treatment of hypertension. It helps lower elevated blood pressure by reducing heart rate and promoting vasodilation, thereby decreasing the workload on the cardiovascular system.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, reducing sympathetic stimulation, heart rate, and contractility. It also stimulates endothelial nitric‑oxide release, causing vasodilation. The combined actions lower systemic vascular resistance and arterial pressure.

The appropriate dose of Nozac is determined by the prescribing healthcare professional based on the individual’s blood‑pressure profile, age, renal and hepatic function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for nebivolol in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To order Nozac, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nebivolol differs from many antihypertensives by combining selective β1‑blockade with nitric‑oxide‑mediated vasodilation, offering both heart‑rate reduction and arterial relaxation. Compared with non‑selective beta‑blockers, it has fewer bronchospastic effects, and unlike pure vasodilators, it also lowers heart rate, providing a balanced blood‑pressure‑lowering profile.

Nozac should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments.

Nozac is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious risks include severe bradycardia, marked hypotension, and rare allergic reactions such as angio‑edema. Patients should seek immediate medical attention if they experience fainting, very slow heart rate, severe dizziness, or signs of an allergic response.

Nozac is contraindicated in patients with known hypersensitivity to nebivolol or any excipients, those with severe bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, and individuals with uncompensated heart failure. Caution is also advised in patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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