Product image of Nubral (Urea) supplied by GNH India

Nubral

Active Ingredient:
Urea
Origin:
EU

Nubral (Urea)

Urea, the active ingredient in Nubral, is a keratolytic agent presented as a topical formulation for dermatological use. It helps manage hyperkeratotic skin conditions in adults.

GNH India supplies Nubral as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Galderma Laboratorium Gmbh

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Indications & Clinical Uses

Urea is used in dermatology to address disorders involving abnormal keratinization.

  • Ichthyosis: reduces scaling and improves skin hydration.
  • Psoriasis: softens plaques and decreases thickness.
  • Xerosis (dry skin): restores moisture and smoothness.

How It Works

  • Urea acts as a hygroscopic molecule that disrupts hydrogen bonds in the stratum corneum, increasing water retention and softening keratin. At higher concentrations it exhibits proteolytic activity, breaking down excess keratin and promoting desquamation, thereby normalizing skin texture and barrier function.

Side Effects

Urea is generally well tolerated, but local reactions may occur.

Common Side Effects

  • Stinging sensation: mild transient discomfort at the application site.
  • Burning: brief heat feeling during initial use.
  • Mild erythema: slight redness that usually resolves.
  • Itching: occasional pruritus, especially on sensitive skin.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): requires immediate medical attention.
  • Contact dermatitis: persistent rash or swelling.
  • Skin ulceration: breakdown of skin integrity with prolonged irritation.
  • Excessive skin peeling: pronounced desquamation beyond expected levels.

Precautions & Warnings

Before using Nubral, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before application.
  • Breastfeeding: use with caution and under medical advice.
  • Skin integrity: avoid applying on open wounds or severely damaged skin.
  • Allergy: discontinue use if hypersensitivity signs appear.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Urea has limited systemic interactions, but topical combinations may affect tolerability.

Major Interactions (Avoid)

  • Concurrent use with other keratolytic agents (e.g., salicylic acid) may cause excessive irritation.
  • None reported: no major drug‑drug interactions identified.

Moderate Interactions (Monitor Closely)

  • Use with occlusive dressings may increase local irritation.
  • Combining with topical antibiotics may raise the risk of contact dermatitis.
  • Application with alcohol‑based products may reduce efficacy.

Frequently Asked Questions

Nubral contains urea and is applied topically to manage dry skin, ichthyosis and psoriasis. It helps soften thickened skin, reduce scaling, and improve overall skin hydration in these dermatological conditions.

Urea acts as a humectant and keratolytic. It attracts water into the outer skin layer, increasing moisture, while at higher concentrations it breaks down excess keratin, facilitating gentle exfoliation and smoother skin.

The dosage of Nubral is determined by the prescribing healthcare professional based on the specific condition, severity, and patient factors. The prescriber will advise the appropriate amount and frequency of application.

Urea is generally considered low risk, but pregnant or breastfeeding individuals should discuss use with their doctor. The prescriber will weigh potential benefits against any theoretical risks before recommending treatment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Nubral’s urea formulation offers both moisturizing and keratolytic actions, whereas agents like salicylic acid primarily exfoliate without significant humectant effect. Urea is often better tolerated on sensitive skin and provides dual benefits of hydration and softening.

Store Nubral at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct heat, and ensure the container is tightly closed when not in use.

Nubral is applied topically to the affected skin area. Clean and dry the skin, then spread a thin layer of the product as directed by the healthcare provider, usually once or twice daily, and gently massage until absorbed.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, contact dermatitis, and skin ulceration from excessive irritation. Users should stop treatment and seek medical attention if these symptoms develop.

Individuals with known hypersensitivity to urea or any excipients in the formulation should avoid Nubral. It should also not be applied to broken or infected skin without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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