Numark Anti-Diarrhoea (Loperamide Hydrochloride)

Loperamide acts on peripheral μ‑opioid receptors in the gut wall, inhibiting the release of acetylcholine and other neurotransmitters that stimulate peristalsis. This reduces the speed of intestinal transit, increases the time for water and electrolytes to be absorbed, and strengthens the anal sphincter, resulting in firmer, less frequent stools.

The exact dose of Numark Anti-Diarrhoea is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms, and clinical condition. Patients should follow the prescriber’s instructions and not self‑adjust the dosage.

Loperamide is generally classified as Category C for pregnancy, meaning risk cannot be ruled out. It should only be used if the potential benefit justifies the potential risk to the fetus. During breastfeeding, small amounts may pass into milk; use only if clearly needed and after consulting a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with other over‑the‑counter antidiarrheals such as diphenoxylate‑atropine, loperamide has minimal central nervous system activity because it does not readily cross the blood‑brain barrier. This makes it effective for peripheral gut motility control while reducing the risk of central opioid effects.

Store Numark Anti‑Diarrhoea at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments.

Numark Anti‑Diarrhoea is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed. Patients should follow the dosing schedule prescribed by their clinician and may be advised to take the medication after the first loose stool.

Serious risks include severe constipation that can lead to bowel obstruction, toxic megacolon, allergic reactions such as rash or swelling, and cardiac arrhythmias (especially when combined with other QT‑prolonging drugs). Any signs of these conditions require immediate medical attention.

Numark Anti‑Diarrhoea should be avoided in patients with known hypersensitivity to loperamide, those with acute dysentery or colitis caused by invasive bacteria, and individuals with severe hepatic impairment. It is also contraindicated in children under two years of age unless specifically directed by a pediatric specialist.