Product image of Numark Sleep Aid (Diphenhydramine Hydrochloride) supplied by GNH India

Numark Sleep Aid

Active Ingredient:
Diphenhydramine Hydrochloride
Origin:
EU

Numark Sleep Aid (Diphenhydramine Hydrochloride)

Diphenhydramine Hydrochloride, the active ingredient in Numark Sleep Aid, is a first‑generation antihistamine presented as a tablet for oral use. It is commonly used to promote sleep and relieve occasional sleeplessness in adults.

GNH India supplies Numark Sleep Aid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Omega Pharma Ltd

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Indications & Clinical Uses

Numark Sleep Aid contains diphenhydramine, an antihistamine that acts on histamine receptors to induce sedation. It is indicated for:

  • Short‑term insomnia: helps adults fall asleep faster and reduces nighttime awakenings.
  • Motion sickness prevention: alleviates nausea and dizziness associated with travel.
  • Allergic rhinitis symptom relief: reduces sneezing, itching and watery eyes, which can indirectly improve sleep quality.

How It Works

  • Diphenhydramine Hydrochloride blocks H1 histamine receptors in the central nervous system, reducing histamine‑mediated wakefulness. By crossing the blood‑brain barrier, it also exerts anticholinergic activity that contributes to its sedative‑hypnotic effect, facilitating the onset of sleep.

Side Effects

Side effects vary in frequency and severity.

Common Side Effects

  • Drowsiness or prolonged sedation
  • Dry mouth
  • Blurred vision
  • Constipation
  • Urinary retention
  • Dizziness

Serious or Rare Side Effects

  • Severe allergic reactions (anaphylaxis, angioedema)
  • Cardiac arrhythmias
  • Hallucinations or severe confusion
  • Seizures
  • Persistent tachycardia

Precautions & Warnings

Before using Numark Sleep Aid, consider the following safety measures:

  • Pregnancy and lactation: consult the risk benefit assessment with your health care provider.
  • Elderly patients: start with a lower dose and monitor for anticholinergic effects.
  • Concomitant CNS depressants: avoid combined use to reduce excessive sedation.
  • Pre‑existing glaucoma, urinary retention, or enlarged prostate: use with caution.
  • Liver or kidney impairment: dose adjustment may be required.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Diphenhydramine may interact with several medicines. Review 

Major Interactions (Avoid)

  • Alcohol : Increases the risk of profound sedation and respiratory resp ​ ​  

g  g  Moderate Interactions (Monitor Closely):

  • Antifungal : May increase the plasma level of dip 

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Frequently Asked Questions

Numark Sleep Aid contains diphenhydramine hydrochloride, a first‑generation antihistamine that is used primarily to help adults with short‑term insomnia fall asleep. It is also employed to relieve symptoms of motion sickness and allergic rhinitis that can interfere with sleep.

Diphenhydramine blocks H1 histamine receptors in the brain, reducing the wake‑promoting effects of histamine. Its ability to cross the blood‑brain barrier also produces anticholinergic activity, which together create a sedative‑hypnotic effect that helps initiate and maintain sleep.

The appropriate dose of Numark Sleep Aid is determined by a qualified prescriber based on the individual’s age, medical condition, and response to therapy. Patients should follow the prescribing information and not exceed the recommended amount.

Safety of diphenhydramine during pregnancy or lactation should be evaluated by a healthcare professional. The prescriber will weigh potential benefits against risks and advise whether the medication is appropriate for use in these situations.

To request Numark Sleep Aid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Numark Sleep Aid (diphenhydramine) is a first‑generation antihistamine, differing from prescription hypnotics such as zolpidem or melatonin receptor agonists. It is available over‑the‑counter in many regions, but may cause more anticholinergic side effects than newer agents that target specific sleep pathways.

Store Numark Sleep Aid at ambient temperature, below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Numark Sleep Aid is taken orally as a tablet, typically with a glass of water. It is usually taken shortly before bedtime, following the dosage instructions provided by the prescriber.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, cardiac arrhythmias, hallucinations, and seizures. Patients should seek immediate medical attention if they experience any signs of a serious reaction.

Numark Sleep Aid should be avoided by individuals with known hypersensitivity to diphenhydramine or other antihistamines, those with severe asthma, untreated narrow‑angle glaucoma, or significant urinary retention. It is also contraindicated in newborns and infants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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