Numeta G (Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine, Methio)

Numeta G is used as a component of parenteral nutrition regimens for patients with complex metabolic demands. It provides essential amino acids to support:

• Critical illness: helps maintain nitrogen balance and supports tissue repair.
• Neonatal care: supplies necessary amino acids for growth in preterm infants.
• Post‑surgical recovery: contributes to protein synthesis during convalescence.
• Severe malnutrition: assists in rebuilding lean body mass.
• Metabolic disorders: offers a controlled amino acid profile for specific inborn errors.
• Long‑term home parenteral nutrition: enables outpatient amino acid supplementation.

• Numeta G delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream, bypassing gastrointestinal absorption. The amino acids serve as substrates for protein synthesis, support gluconeogenesis, and replenish nitrogen stores, thereby sustaining cellular metabolism and tissue repair in patients who cannot obtain adequate nutrition enterally.

Numeta G may be associated with infusion‑related reactions and metabolic disturbances.

Common Side Effects

• Hyperglycaemia: elevated blood glucose during infusion.
• Electrolyte shifts: changes in potassium, sodium or calcium levels.
• Mild fever or chills: transient temperature rise.
• Local irritation: redness or discomfort at the IV site.
• Nausea: occasional feeling of queasiness.
• Headache: mild, transient headache.

Serious or Rare Side Effects

• Anaphylaxis: severe allergic reaction requiring immediate medical attention.
• Metabolic acidosis: significant pH imbalance.
• Hyperammonemia: elevated ammonia levels in blood.
• Sepsis: infection linked to catheter use.
• Thrombophlebitis: vein inflammation with clot formation.
• Renal impairment: worsening kidney function in susceptible patients.

Before initiating Numeta G, clinicians should assess patient-specific factors and monitor relevant parameters.

• Renal function: evaluate baseline creatinine and adjust infusion rates if impaired.
• Hepatic function: monitor liver enzymes in patients with liver disease.
• Electrolyte balance: check serum electrolytes prior to and during therapy.
• Glycaemic control: monitor blood glucose in diabetic or hyperglycaemic patients.
• Allergic history: review prior reactions to amino‑acid solutions.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

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