Product image of Numeta G16e (Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine, Methio) supplied by GNH India

Numeta G16e

Active Ingredient:
Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine, Methio
Origin:
EU

Numeta G16e (Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine, Methio)

Valine, the active ingredient in Numeta G16e, is a parenteral nutrition supplement presented as a sterile aqueous solution for intravenous use. It supports metabolic needs in patients requiring comprehensive amino acid support, particularly in critical care and postoperative settings. GNH India supplies Numeta G16e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

GNH India supplies Numeta G16e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Baxter Oy

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Indications & Clinical Uses

Numeta G16e is used in clinical nutrition to address amino‑acid deficiencies associated with critical illness and extensive surgery.

  • Critical care nutrition: Provides balanced amino acids to support protein synthesis and nitrogen balance.
  • Post‑operative recovery: Helps maintain lean body mass during the catabolic phase after major surgery.
  • Long‑term parenteral nutrition: Supplies essential amino acids for patients on home or institutional PN.
  • Metabolic support in severe trauma: Contributes to tissue repair and immune function.
  • Pre‑transplant conditioning: Assists in optimizing nutritional status before organ transplantation.

How It Works

  • Numeta G16e delivers a mixture of essential and conditionally essential amino acids directly into the bloodstream, bypassing gastrointestinal absorption. The amino acids serve as substrates for protein synthesis, support gluconeogenesis, and replenish nitrogen stores, thereby aiding tissue repair, immune function, and metabolic stability in patients unable to meet nutritional needs orally or enterally.

Side Effects

Numeta G16e may be associated with infusion‑related reactions and metabolic disturbances.

Common Side Effects

  • Mild fever or chills during infusion.
  • Transient elevation of blood urea nitrogen.
  • Slight increase in serum ammonia levels.
  • Local irritation at the catheter site.
  • Minor electrolyte shifts (e.g., potassium, calcium).

Serious or Rare Side Effects

  • Severe hypersensitivity or anaphylaxis.
  • Hyperosmolar hyperglycemic events.
  • Significant metabolic acidosis.
  • Persistent hypernatremia.
  • Thrombophlebitis or catheter‑related bloodstream infection.

Precautions & Warnings

When using Numeta G16e, clinicians should assess individual patient needs and monitor relevant parameters.

  • Renal function: Adjust infusion rate in patients with impaired renal clearance.
  • Hepatic function: Monitor ammonia and liver enzymes in liver disease.
  • Electrolytes: Check serum electrolytes before and during therapy.
  • Glycemic control: Observe blood glucose in diabetic or hyperglycaemic patients.
  • Catheter care: Use aseptic technique to reduce infection risk.
  • Store at 2‑8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Numeta G16e contains amino acids that can influence the metabolism of certain drugs and electrolytes.

Major Interactions (Avoid)

  • High‑dose phenylalanine supplements: May exacerbate metabolic imbalance.
  • Potassium‑sparing diuretics: Risk of hyperkalaemia when combined with amino‑acid solutions.

Moderate Interactions (Monitor Closely)

  • Insulin therapy: Amino acids can affect glucose levels, requiring dose adjustment.
  • Anticonvulsants (e.g., valproate): May alter plasma amino‑acid concentrations.
  • Loop diuretics: Potential for electrolyte disturbances.
  • Corticosteroids: May increase protein catabolism, influencing amino‑acid requirements.
  • Parenteral lipid emulsions: Co‑administration can affect osmolarity and infusion compatibility.

Frequently Asked Questions

Numeta G16e is an intravenous amino‑acid solution used to provide comprehensive nutritional support for patients who cannot receive adequate nutrition orally or enterally, such as those in intensive care, after major surgery, or on long‑term parenteral nutrition programs.

Valine and the accompanying amino acids are delivered directly into the bloodstream, where they act as building blocks for protein synthesis, support nitrogen balance, and serve as substrates for gluconeogenesis, helping maintain metabolic stability in critically ill patients.

The dose of Numeta G16e is individualized by the prescribing clinician based on the patient’s weight, metabolic needs, and clinical condition. Healthcare professionals calculate the appropriate infusion rate and total daily amount according to established nutrition protocols.

Safety data for Numeta G16e in pregnancy and lactation are limited. It should only be used when clearly needed and after a risk‑benefit assessment by the treating physician, as the amino‑acid composition may affect maternal and fetal metabolism.

To order, submit an enquiry on the Numeta G16e product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Numeta G16e offers a balanced profile of essential and conditionally essential amino acids, similar to other high‑quality parenteral nutrition solutions. Compared with simpler formulations, it provides a broader amino‑acid spectrum, which can better support protein synthesis and metabolic needs in severely ill patients.

Numeta G16e should be stored at 2‑8°C, protected from light, and must not be frozen or shaken. Before use, inspect the container for particulate matter and ensure the solution is at room temperature if required for infusion.

Numeta G16e is administered intravenously, typically via a central or peripheral venous catheter. The infusion rate is set according to the patient’s prescribed daily amino‑acid requirement and may be given continuously or in divided doses as directed by the clinical nutrition team.

Serious risks include severe hypersensitivity reactions, metabolic acidosis, hyperosmolar hyperglycaemic events, and catheter‑related bloodstream infections. Prompt recognition and management of these events are essential, and patients should be closely monitored during therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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