Nuperal (Doxylamine Hydrogen Succinate, Pyridoxine Hydrochloride)

Doxylamine hydrogen succinate blocks H1 histamine receptors in the brain and peripheral tissues. By preventing histamine from binding, it reduces the stimulation that can cause nausea, vomiting, and wakefulness. This antihistaminic action, together with pyridoxine’s role as a metabolic co‑factor, contributes to its anti‑emetic and sedative effects.

The appropriate dose of Nuperal is determined by a qualified healthcare professional based on the individual’s age, condition, and response to therapy. Patients should follow the prescriber’s instructions and not exceed the recommended amount indicated on the product label.

Nuperal is commonly used for nausea in early pregnancy, but its safety should be evaluated by a healthcare provider. Pyridoxine is a vitamin B6 considered safe in pregnancy, while doxylamine is classified as a Category B drug in many regions. Breastfeeding mothers should consult their physician before use.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with alternatives such as diphenhydramine, Nuperal combines an antihistamine with vitamin B6, which may improve tolerability for nausea while still providing sedation. Diphenhydramine lacks the pyridoxine component and is often associated with a higher incidence of anticholinergic side effects. Choice of therapy should be guided by clinical need and physician advice.

Store Nuperal at ambient temperature, preferably below 25 °C, in its original container. Protect the tablets from moisture, direct sunlight and excessive heat. Keep out of reach of children and ensure the packaging remains sealed until use.

Nuperal is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional. It is generally taken at bedtime for sleep aid or as prescribed for nausea relief.

Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, cardiac arrhythmias, seizures, marked dizziness leading to falls, and liver dysfunction. Patients experiencing any of these symptoms should seek immediate medical attention.

Individuals with known hypersensitivity to doxylamine, pyridoxine, or any component of the formulation should avoid Nuperal. It is also contraindicated in patients with severe asthma, uncontrolled glaucoma, urinary retention, or those taking monoamine oxidase inhibitors. Pregnant women in the first trimester should consult a physician before use.