Nureflex Junior Erdbeer (Ibuprofen)

Ibuprofen is an NSAID that alleviates pain, reduces fever, and diminishes inflammation by blocking prostaglandin production.

• Mild to moderate pain: provides effective analgesic relief for headaches, toothaches, and minor injuries.
• Fever: lowers elevated body temperature in children with acute infections.
• Inflammatory conditions (e.g., minor sprains): decreases swelling and discomfort associated with soft‑tissue inflammation.

• Ibuprofen exerts its therapeutic effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition reduces the synthesis of prostaglandins, which are mediators of pain, fever, and inflammation, thereby providing analgesic, antipyretic, and anti‑inflammatory actions at the site of tissue injury or infection.

Ibuprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

• Stomach upset or dyspepsia: mild gastrointestinal discomfort.
• Nausea or vomiting: occasional upset stomach.
• Heartburn: burning sensation in the chest.
• Dizziness: transient light‑headedness.
• Rash or mild skin irritation: minor dermatologic response.
• Headache: occasional mild headache.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration: severe stomach or intestinal bleeding.
• Severe allergic reaction (anaphylaxis): rapid onset of hives, swelling, and breathing difficulty.
• Liver enzyme elevation: signs of hepatic stress.
• Kidney impairment: reduced renal function, especially with dehydration.
• Stevens‑Johnson syndrome: rare but serious skin disorder.

When using ibuprofen, consider the following precautions to minimize risks and ensure safe use.

• Assess medical history: check for asthma, ulcer disease, kidney or liver impairment.
• Age restriction: avoid use in children under the age recommended on the label unless directed by a clinician.
• Concomitant NSAIDs: do not combine with other NSAIDs or aspirin without medical advice.
• Alcohol consumption: limit intake while using ibuprofen to reduce gastrointestinal risk.
• Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Ibuprofen can interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleed risk.
• Corticosteroids: elevated ulcer and gastrointestinal complication risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors: potential reduction in renal function.
• Diuretics: may affect kidney clearance of ibuprofen.
• Lithium: possible increase in serum lithium levels.