Nuridol (Paracetamol)

Nuridol (paracetamol) is used to relieve pain and fever by acting on the body's temperature‑regulation and pain pathways.

• Headache: reduces pain intensity and improves daily functioning.
• Fever: lowers elevated body temperature to normal range.
• Musculoskeletal pain: alleviates aches associated with back, joint or muscle strain.
• Dental pain: provides relief after dental procedures or toothache.
• Common cold symptoms: eases discomfort from sore throat and mild body aches.

• Paracetamol reduces fever and pain by inhibiting the cyclo‑cyclooxygenase (COX) enzymes in the central nervous system, which lowers prostaglandin synthesis. This action modulates the hypothalamic heat‑regulation centre and diminishes pain signal transmission, providing antipyretic and analgesic effects without significant peripheral anti‑inflammatory activity.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: mild stomach upset that resolves without treatment.
• Rash: transient skin redness or itching.
• Elevated liver enzymes: mild, reversible increase detected in blood tests.
• Headache: occasional worsening of existing headache.
• Dizziness: brief sensation of light‑headedness.

Serious or Rare Side Effects

• Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
• Toxic hepatitis: liver injury presenting with jaundice, fatigue and abdominal pain.
• Anaphylaxis: rare allergic reaction with breathing difficulty and swelling.
• Blood disorders: agranulocytosis or thrombocytopenia in extremely rare cases.
• Severe skin necrosis: extensive skin damage needing urgent care.

When using Nuridio, consider the following safety measures:

• Dosage limits: adhere to maximum daily intake to avoid liver toxicity.
• Alcohol use: limit consumption as it increases risk of liver damage.
• Pre‑existing liver disease: use only under medical supervision.
• Pregnancy and lactation: consult healthcare professional before use.
• Concomitant medications: review all current drugs with a pharmacist.
• Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Paracetamol can interact with several medicines, affecting its safety and efficacy.

Major Interactions (Avoid)

• Warfarin: may increase bleeding risk due to enhanced anticoagulant effect.
• Isoniazid: combined use can raise risk of liver toxicity.

Moderate Interactions (Monitor Closely)

• Antiepileptic drugs (e.g., carbamazepine, phenytoin): may reduce paracetamol plasma levels.
• HIV protease inhibitors: can alter metabolism, requiring dose adjustment.
• Rifampicin: may increase hepatic metabolism, lowering effectiveness.
• Oral contraceptives: may slightly reduce efficacy, monitor cycle.
• High‑dose vitamin C: may affect renal clearance of paracetamol metabolites.