Nurofen 200 Fastcaps (Ibuprofen)

• Ibuprofen, an NSAID that reduces prostaglandin-mediated inflammation, is indicated for the following conditions:
• Pain: Provides relief from mild to moderate pain such as headache, toothache, menstrual cramps, and musculoskeletal discomfort.
• Fever: Lowers elevated body temperature associated with infections or other febrile states.
• Inflammation: Alleviates inflammatory processes in conditions like minor injuries, arthritis flare‑ups, and postoperative swelling.

• Ibuprofen exerts its effect by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which catalyze the conversion of arachidonic acid to prostaglandins. By decreasing prostaglandin synthesis, it reduces inflammation, lowers fever, and diminishes peripheral and central pain signaling.

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

• Gastro‑intestinal discomfort: nausea, dyspepsia, or mild abdominal pain.
• Headache: occasional tension‑type headache.
• Dizziness: transient light‑headedness.
• Skin reactions: mild rash or itching.
• Elevated blood pressure: occasional increase.

Serious or Rare Side Effects

• Gastro‑intestinal ulceration or bleeding.
• Severe allergic reactions such as anaphylaxis or angioedema.
• Hepatotoxicity or significant liver enzyme elevation.
• Renal impairment or acute kidney injury.
• Cardiovascular events including myocardial infarction or stroke (rare).

Before using Nurofen 200 Fastcaps, consider the following precautions:

• Assess medical history: check for ulcers, bleeding disorders, heart disease, kidney or liver disease.
• Avoid concurrent NSAIDs or aspirin unless directed by a healthcare professional.
• Do not exceed the recommended daily amount set by your prescriber.
• Take with food or milk to lessen stomach irritation.
• Monitor for signs of allergic reaction such as rash, swelling, or breathing difficulty.
• Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Ibuprofen can interact with several medicines; review the following categories.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin, DOACs): increased risk of bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Corticosteroids: heightened ulcer risk.
• Selective serotonin reuptake inhibitors (SSRIs): increased bleeding tendency.
• ACE inhibitors or diuretics: may reduce renal function.

Moderate Interactions (Monitor Closely)

• Lithium: ibuprofen may raise lithium serum levels.
• Methotrexate: reduced clearance leading to toxicity.
• Blood pressure medications (ACE inhibitors, ARBs): monitor renal function.
• Diuretics: watch for dehydration and renal effects.
• Antihypertensives: possible reduction in efficacy.