Nurofen 24-Stunden Schmerzpflaster (Ibuprofen)

Nurofen 24-Stunden Schmerzpflaster contains ibuprofen, a non‑steroidal anti‑inflammatory that acts on prostaglandin synthesis in musculoskeletal tissues.

• Musculoskeletal pain: provides up to 24 hours of localized relief for strains, sprains and minor joint aches.
• Post‑operative pain: reduces discomfort at the surgical site when applied after minor procedures.
• Chronic low‑back pain: helps manage persistent lumbar discomfort through continuous transdermal delivery.

• Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes in peripheral tissues, decreasing the formation of prostaglandins that mediate pain, inflammation and fever. The transdermal patch delivers the drug directly to the skin, allowing local COX inhibition at the site of discomfort while limiting systemic exposure.

Adverse reactions to the ibuprofen patch are generally mild to moderate and reflect its anti‑inflammatory action.

Common Side Effects

• Skin irritation at the application site: redness, itching or mild rash.
• Localized burning sensation: transient warmth where the patch is placed.
• Dryness of the surrounding skin: mild flaking or peeling.
• Pruritus: itching without visible rash.

Serious or Rare Side Effects

• Severe allergic reaction: swelling of face, lips or throat, hives, or difficulty breathing.
• Systemic ibuprofen toxicity: gastrointestinal bleeding, ulceration or renal impairment, especially with extensive use.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis: widespread skin detachment.
• Anaphylaxis: rapid onset of hypotension, bronchospasm and loss of consciousness.

When using Nurofen 24-Stunden Schmerzpflaster, consider the following safety measures:

• Contraindications: avoid if known allergy to ibuprofen or other NSAIDs.
• Pregnancy: limit use; consult a healthcare professional, especially in the third trimester.
• Renal function: assess kidney health before prolonged application.
• Concomitant NSAIDs: do not combine with other oral or topical NSAIDs to reduce risk of toxicity.
• Skin integrity: apply only to intact, non‑irritated skin; discontinue if severe irritation occurs.
• Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Ibuprofen may interact with several drug classes; monitoring is advised.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• High‑dose aspirin: heightened gastrointestinal toxicity.
• Selective COX‑2 inhibitors: additive renal and cardiovascular risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.
• Diuretics (especially thiazides): risk of reduced renal perfusion.
• Lithium: ibuprofen can raise serum lithium levels.
• Methotrexate: decreased renal clearance may increase toxicity.