Nurofen 400 Fasttabs (Ibuprofen Lysine)

Nurofen 400 Fasttabs contains ibuprofen lysine, which acts on inflammatory pathways to provide analgesic and antipyretic effects.

• Headache: reduces pain intensity and associated discomfort.
• Dental pain: alleviates post‑extraction or procedural soreness.
• Musculoskeletal pain: eases aches from strains, sprains or over‑use.
• Fever: lowers elevated body temperature in acute febrile states.
• Menstrual discomfort: diminishes cramping and lower‑abdominal pain.

• Ibuprofen lysine is a reversible inhibitor of cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. By limiting prostaglandin production at sites of tissue injury, it provides analgesic, antipyretic and anti‑inflammatory effects.

Adverse reactions to ibuprofen lysine may vary in frequency and severity.

Common Side Effects

• Gastro‑intestinal discomfort such as dyspepsia or heartburn.
• Nausea or mild vomiting.
• Headache or dizziness.
• Mild skin rash or itching.

Serious or Rare Side Effects

• Gastro‑intestinal ulceration or bleeding.
• Severe allergic reactions including anaphylaxis.
• Elevated liver enzymes or hepatic injury.
• Renal impairment or acute kidney injury.
• Cardiovascular events such as myocardial infarction or stroke.

When considering ibuprofen lysine therapy, several safety measures should be observed.

• Assess gastrointestinal risk: avoid use in patients with active ulcers or a history of GI bleeding.
• Evaluate renal function: use cautiously in those with impaired kidney function.
• Monitor cardiovascular status: limit use in patients with established heart disease.
• Review concomitant medications: avoid concurrent NSAIDs or anticoagulants without medical guidance.
• Pregnancy and lactation: consult a healthcare professional before use.
• Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Ibuprofen lysine can interact with a range of medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened bleeding risk.
• High‑dose aspirin aspirin  : increased gastrointestinal toxicity.\nModerate Interactions (Monitor Closely):
• ACE‑ inhibitors (e.g., enalapril): possible reduction in renal perfusion.
• Diuretics (e.g., furosemide) :  
• Selective serotonin reuptake‑relabels   \n-   "  "  "  "  "  "  "  "  "  "   "  "  " ...