Nurofen 400 Female (Ibuprofen Lysine)

Ibuprofen lysine acts systemically to reduce pain, inflammation and fever across several common conditions.

• Headache: provides relief from tension‑type and mild migraine headaches.
• Dental pain: alleviates pain following dental procedures or toothache.
• Musculoskeletal pain: reduces discomfort from sprains, strains and minor joint aches.
• Menstrual discomfort: eases cramps and associated lower‑abdominal pain.
• Fever: helps lower elevated body temperature in acute febrile episodes.

• Ibuprofen lysine inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain signalling and fever. By reducing prostaglandin levels, it dampens peripheral nociceptor sensitisation and central fever pathways, providing analgesic and antipyretic effects.

Adverse reactions to ibuprofen lysine can vary in frequency and severity.

Common Side Effects

• Gastrointestinal discomfort: mild nausea, dyspepsia or heartburn.
• Headache: transient headache unrelated to the condition being treated.
• Dizziness: occasional light‑headed sensation.
• Rash: mild skin erythema or itching.
• Elevated blood pressure: modest rise in systolic or diastolic values.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Severe allergic reactions: anaphylaxis, angio‑edema.
• Hepatic injury: marked elevation of liver enzymes.
• Renal impairment: acute kidney injury, especially with dehydration.
• Cardiovascular events: increased risk of myocardial infarction or stroke.

When considering ibuprofen lysine therapy, several safety measures are recommended.

• Assess gastrointestinal risk: avoid in patients with active ulcers or severe dyspepsia.
• Evaluate cardiovascular status: use cautiously in those with hypertension or heart disease.
• Monitor renal function: contraindicated in severe renal impairment.
• Review concomitant medications: avoid concurrent use with other NSAIDs or anticoagulants without supervision.
• Pregnancy and lactation: limit use to the lowest effective duration and only if benefits outweigh risks.
• Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Ibuprofen lysine may alter the efficacy or safety profile of several co‑administered medicines.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• High‑dose aspirin: heightened gastrointestinal toxicity.
• Selective COX‑2 inhibitors: additive renal and cardiovascular adverse effects.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.
• Diuretics: enhanced risk of renal impairment.
• Lithium: increased serum lithium concentrations.
• Methotrexate: reduced renal clearance leading to toxicity.