Nurofen Cold And Flu (Pseudoephedrine Hydrochloride, Ibuprofen)

Nurofen Cold and Flu combines an NSAID and a nasal decongestant to address multiple symptoms of upper respiratory infections.

• Common Cold and Flu: provides analgesic, antipyretic and decongestant relief of headache, fever, sore throat and nasal blockage.
• Sinusitis: reduces sinus pressure and associated pain.
• Musculoskeletal aches: alleviates body aches that often accompany viral infections.

• Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation, pain, and fever. Pseudoephedrine acts as a sympathomimetic amine, stimulating α‑adrenergic receptors in nasal mucosal vessels, causing vasoconstriction and reduced nasal edema, which improves airway patency.

Nurofen Cold and Flu may cause a range of adverse reactions, from mild to severe.

Common Side Effects

• Nausea: mild gastrointestinal upset.
• Headache: transient discomfort.
• Dizziness: occasional light‑headedness.
• Insomnia: difficulty sleeping.
• Dry mouth: reduced salivation.
• Increased blood pressure: mild elevation.

Serious or Rare Side Effects

• Gastrointestinal bleeding: ulceration or hemorrhage.
• Severe allergic reaction: rash, swelling, anaphylaxis.
• Hepatic injury: elevated liver enzymes.
• Renal impairment: reduced kidney function.
• Cardiovascular events: heart attack or stroke.
• Severe skin reactions: Stevens‑Johnson syndrome.

Before using Nurofen Cold and Flu, consider the following safety measures.

• Assess cardiovascular risk: pseudoephedrine may raise blood pressure.
• Avoid in active ulcer disease: ibuprofen can irritate the gastrointestinal lining.
• Check renal function: both agents may affect kidney performance.
• Use with caution in pregnancy after the first trimester: NSAIDs are contraindicated and pseudoephedrine should be avoided.
• Do not combine with MAO inhibitors: risk of hypertensive crisis.
• Store at ambient temperature: keep in the original pack, protect from moisture.

Nurofen Cold and Flu can interact with several medicines; some require avoidance while others need monitoring.

Major Interactions (Avoid)

• MAO inhibitors: may cause hypertensive crisis with pseudoephedrine.
• Anticoagulants (e.g., warfarin): ibuprofen can increase bleeding risk.
• Lithium: pseudoephedrine may raise lithium serum levels.

Moderate Interactions (Monitor Closely)

• Beta‑blockers: may blunt the decongestant effect of pseudoephedrine.
• SSRIs: combined use can increase risk of gastrointestinal bleeding.
• Alcohol: additive irritation to the gastrointestinal tract.