Product image of Nurofen Day & Night Cold & Flu (Phenylephrine Hydrochloride, Ibuprofen Bp) supplied by GNH India

Nurofen Day & Night Cold & Flu

Active Ingredient:
Phenylephrine Hydrochloride, Ibuprofen Bp
Origin:
EU

Nurofen Day & Night Cold & Flu (Phenylephrine Hydrochloride, Ibuprofen Bp)

Ibuprofen and phenylephrine hydrochloride, the active ingredients in Nurofen Day & Night Cold & Flu, are a non‑steroidal anti‑inflammatory drug and a nasal decongestant respectively, presented as oral tablets for oral use. They are formulated to relieve fever, pain, and nasal congestion associated with cold and flu in adults and children over 12 years of age.

GNH India supplies Nurofen Day & Night Cold & Flu as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies and clinics worldwide.

Manufacturer / TM Owner

Reckitt Benckiser (Healthcare) Uk Ltd

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Indications & Clinical Uses

Nurofen Day & Night Cold & Flu combines an NSAID and a decongestant to address common cold‑and‑flu symptoms.

  • Fever: lowers elevated body temperature.
  • Headache: eases pain associated with sinus pressure.
  • Nasal congestion: reduces swelling of nasal passages for easier breathing.
  • Body aches and sore throat: alleviates muscular discomfort and throat irritation.
  • General flu discomfort: provides overall symptom relief for improved daily functioning.

How It Works

  • Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation, pain, and fever. Phenylephrine hydrochloride acts as an alpha‑1 adrenergic receptor agonist, causing vasoconstriction of nasal mucosal blood vessels, which diminishes swelling and improves airway patency.

Side Effects

Common Side Effects

  • Stomach upset or dyspepsia.
  • Nausea or vomiting.
  • Dizziness or light‑headedness.
  • Headache.
  • Mild skin rash.
  • Dry mouth.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer formation.
  • Severe allergic reactions such as anaphylaxis.
  • Liver enzyme elevation or hepatic injury.
  • Acute kidney injury or reduced renal function.
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome).
  • Cardiovascular events such as hypertension or thrombotic episodes.

Precautions & Warnings

Before using Nurofen Day & Night Cold & Flu, consider the following precautions:

  • Assess medical history: avoid if you have active peptic ulcer, severe heart failure, or uncontrolled hypertension.
  • Review kidney and liver function: use with caution in patients with renal or hepatic impairment.
  • Monitor for asthma: phenylephrine may exacerbate bronchospasm in susceptible individuals.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Drug interactions: discuss all concurrent medications with a clinician.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, and protect from moisture.

Avoid Interactions

Nurofen Day & Night Cold & Flu may interact with several medicines.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • Monoamine oxidase inhibitors (MAOIs): potential hypertensive crisis with phenylephrine.
  • SSRIs or SNRIs: elevated bleeding risk.
  • High‑dose antihypertensives: phenylephrine may counteract blood‑pressure control.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in antihypertensive effect.
  • Diuretics: monitor renal function and electrolytes.
  • Lithium: ibuprofen may increase lithium levels.
  • Corticosteroids: increased risk of gastrointestinal ulceration.
  • Beta‑blockers: phenylephrine may diminish therapeutic response.

Frequently Asked Questions

Nurofen Day & Night Cold & Flu is formulated to provide temporary relief of fever, headache, body aches, sore throat, and nasal congestion that commonly accompany colds and influenza. It combines an NSAID with a nasal decongestant to address both pain and breathing discomfort.

Ibuprofen blocks the cyclo‑oxygenase enzymes (COX‑1 and COX‑2), which reduces the production of prostaglandins—chemicals that cause inflammation, pain, and fever. By lowering prostaglandin levels, ibuprofen helps alleviate pain and reduce elevated body temperature.

The appropriate dose is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and the product label without exceeding the recommended amount.

Pregnant or breastfeeding individuals should consult a healthcare provider before using this product. Ibuprofen is generally avoided in the third trimester, and phenylephrine may affect uterine blood flow, so professional guidance is essential.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Unlike single‑ingredient products, this formulation combines ibuprofen for pain and fever with phenylephrine for nasal decongestion, offering dual‑action relief. Some alternatives may contain paracetamol or antihistamines, which target different symptom pathways, so choice depends on individual symptom profiles and tolerability.

Store the tablets at ambient temperature, below 25 °C, in their original packaging. Keep them away from moisture, direct sunlight, and out of reach of children to maintain product stability.

The product is taken orally with a full glass of water. It can be taken with or without food, but taking it with food may reduce stomach irritation. Follow the prescriber’s dosing schedule for day and night formulations.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, liver or kidney impairment, and cardiovascular events like hypertension. Patients should seek immediate medical attention if they experience symptoms such as vomiting blood, severe abdominal pain, rash, or difficulty breathing.

Individuals with a known allergy to ibuprofen, phenylephrine, or any component of the formulation should avoid this product. It is also contraindicated in patients with active peptic ulcer disease, severe heart failure, uncontrolled high blood pressure, or those taking certain interacting medications without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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