Nurofen Effetto Prolungato 300 Mg Compresse A Rilascio Prolungato (Ibuprofen)

Ibuprofen acts on inflammatory pathways to relieve several common conditions.

• Headache: provides relief from mild to moderate pain associated with tension or vascular headaches.
• Dental pain: reduces pain and swelling after dental procedures or toothache.
• Musculoskeletal pain: eases discomfort from strains, sprains, back pain and minor joint inflammation.
• Fever: lowers elevated body temperature in febrile states.
• Menstrual cramps: alleviates dysmenorrhoeic pain during menstruation.

• Ibuprofen non‑selectively inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. Reduced prostaglandin synthesis leads to diminished inflammation, pain signalling and fever generation, providing symptomatic relief across a range of acute conditions.

Adverse reactions may vary in frequency and severity.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or mild abdominal pain.
• Headache: transient headache not related to the underlying condition.
• Dizziness: occasional light‑headedness or vertigo.
• Skin rash: mild erythema or itching.
• Elevated blood pressure: modest rise in systolic or diastolic values.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding: potentially life‑threatening hemorrhage.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Renal impairment: acute kidney injury, especially with dehydration.
• Hepatotoxicity: elevated liver enzymes or hepatitis.
• Anaphylaxis: acute, potentially fatal allergic reaction.

When using ibuprofen prolonged‑release tablets, consider the following safety measures:

• Assess renal function: evaluate baseline renal status before initiating therapy.
• Monitor cardiovascular risk: patients with hypertension or heart disease should use the lowest effective dose.
• Evaluate gastrointestinal risk: consider gastro‑protective agents for those with a history of ulcers.
• Avoid use in late pregnancy: ibuprofen is contraindicated in the third trimester.
• Review concomitant medications: check for other NSAIDs or anticoagulants.
• Store at below 25°C: keep in the original packaging and protect from moisture.

Ibuprofen may interact with several drug classes; clinical relevance varies.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Selective COX‑2 inhibitors (e.g., celecoxib): additive renal and cardiovascular toxicity.
• High‑dose aspirin aspirin  

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