Nurofen Express (Ibuprofen)

Nurofen Express is an NSAID that provides analgesic and antipyretic effects across several common conditions.

• Headache: Relieves pain and improves daily functioning.
• Dental pain: Reduces post‑procedural discomfort.
• Musculoskeletal pain: Alleviates aches associated with strains, sprains and minor arthritis.
• Fever: Lowers elevated body temperature.
• Menstrual cramps: Diminishes cramp‑related pelvic pain.

• Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. This reduction in prostaglandin levels lessens peripheral sensitisation of nociceptors and lowers the hypothalamic set‑point for temperature regulation.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Gastrointestinal discomfort such as dyspepsia or heartburn.
• Nausea or occasional vomiting.
• Headache.
• Dizziness.
• Mild skin rash.
• Elevated blood pressure in susceptible individuals.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Severe allergic reactions including anaphylaxis.
• Hepatic injury or elevated liver enzymes.
• Renal impairment or acute kidney injury.
• Cardiovascular events such as myocardial infarction or stroke.
• Blood dyscrasias like thrombocytopenia.

Before using Nurofen Express, consider the following safety measures:

• Contraindications: Avoid if you have a known allergy to ibuprofen or other NSAIDs.
• Gastrointestinal risk: Use the lowest effective dose for the shortest duration to minimise ulcer risk.
• Cardiovascular caution: Patients with hypertension or heart disease should consult a physician.
• Renal function: Monitor kidney function in individuals with pre‑existing renal impairment.
• Pregnancy and lactation: Use only under medical advice, especially in the third trimester.
• Store at below 25°C: Keep in the original packaging, protect from moisture and direct sunlight.

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): Increased risk of serious bleeding.
• High‑dose aspirin aspirin: Heightened gastrointestinal toxicity.
• Selective COX‑2 inhibitors (e.g., celecoxib): Additive cardiovascular risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: May reduce antihypertensive effect and affect renal function.
• Diuretics (e.g., furosemide): Potential for reduced renal perfusion.
• Lithium: Ibuprofen may increase serum lithium levels.
• Methotrexate: May decrease renal clearance, raising toxicity risk.