Nurofen Express (Ibuprofen Sodium)

Ibuprofen sodium acts on inflammatory pathways to provide analgesic and antipyretic effects.

• Headache: alleviates pain associated with tension‑type and mild migraine episodes.
• Dental pain: reduces discomfort following dental procedures or toothache.
• Musculoskeletal pain: eases aches from strains, sprains and minor joint inflammation.
• Fever: lowers elevated body temperature in acute febrile states.

• Ibuprofen sodium inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. This reduction in prostaglandin levels dampens peripheral nociceptor sensitisation and lowers the hypothalamic set‑point for body temperature.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Gastrointestinal discomfort such as dyspepsia or heartburn.
• Nausea or occasional vomiting.
• Headache.
• Dizziness.
• Mild skin rash.
• Elevated blood pressure.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Severe allergic reactions including anaphylaxis.
• Hepatic injury or elevated liver enzymes.
• Renal impairment or acute kidney injury.
• Thrombotic events such as myocardial infarction or stroke.
• Severe skin reactions like Stevens‑Johnson syndrome.

Before using Nurofen Express, consider the following safety measures:

• Assess gastrointestinal risk: avoid if you have a history of ulcers or bleeding.
• Cardiovascular caution: use only under medical advice if you have heart disease.
• Renal function: monitor kidney health in patients with pre‑existing renal impairment.
• Pregnancy and lactation: consult a healthcare professional before use.
• Concomitant medications: review all current drugs for potential interactions.
• Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Ibuprofen sodium can interact with several drug classes, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.
• High‑dose aspirin or other NSAIDs: additive gastrointestinal toxicity.
• Selective COX‑2 inhibitors: increased cardiovascular risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.
• Diuretics: may enhance renal impairment.
• Lithium: ibuprofen can raise serum lithium levels.
• Methotrexate: reduced clearance leading to toxicity.