Nurofen Express Forte Mini (Ibuprofen)

Ibuprofen works by inhibiting cyclo‑oxygenase enzymes, providing relief in several common pain‑related and febrile conditions.

• Mild to moderate pain (e.g., headache, dental, musculoskeletal): reduces pain intensity and improves functional ability.
• Fever: lowers elevated body temperature, providing comfort during acute infections or post‑vaccination reactions.
• Inflammatory conditions (e.g., minor sprains, strains, arthritis): diminishes swelling and discomfort associated with inflammation.

• Ibuprofen exerts its effect by non‑selectively inhibiting the cyclo‑oxygenase (COX‑1 and COX‑2) enzymes that catalyze the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it decreases peripheral sensitisation of nociceptors, lowers the hypothalamic set‑point for temperature regulation, and limits inflammatory mediator release, resulting in analgesic, antipyretic and anti‑inflammatory actions.

Ibuprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

• Gastrointestinal discomfort or dyspepsia.
• Headache.
• Dizziness.
• Skin rash or mild itching.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome.
• Renal impairment, especially with prolonged use.
• Hepatotoxicity, manifested as elevated liver enzymes.

Before using Nurofen Express Forte Mini, consider the following precautions to minimise risk.

• Assess gastrointestinal risk: avoid use in patients with active ulcers or a history of GI bleeding.
• Monitor renal function: use cautiously in individuals with impaired kidney function or dehydration.
• Cardiovascular caution: limit use in patients with established heart disease or hypertension.
• Drug interactions: review concomitant medications, especially anticoagulants and other NSAIDs.
• Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

Ibuprofen can interact with several medicines; the significance of the interaction determines the required management.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Lithium: may raise lithium serum levels.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce renal function.
• SSRIs: potential for increased bleeding tendency.