Product image of Nurofen (Ibuprofen) supplied by GNH India

Nurofen

Active Ingredient:
Ibuprofen
Origin:
EU

Nurofen (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a transdermal formulation for topical use. It is employed to relieve pain, reduce fever, and diminish inflammation in adults and, where appropriate, children.
GNH India supplies Nurofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Reckitt Benckiser Kft

1
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Indications & Clinical Uses

Ibuprofen acts systemically on prostaglandin pathways to manage several common conditions.

  • Pain relief: alleviates mild to moderate pain such as headaches, muscle aches, and joint discomfort.
  • Fever reduction: lowers elevated body temperature associated with infections or inflammatory states.
  • Inflammation reduction: decreases swelling and redness in conditions like minor sprains or arthritic flare‑ups.

How It Works

  • Ibuprofen inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which reduces the synthesis of prostaglandins responsible for pain, fever, and inflammation. By limiting prostaglandin production at the site of tissue injury, the drug diminishes nociceptor sensitisation and vascular permeability, providing symptomatic relief.

Side Effects

Adverse reactions may occur with topical ibuprofen use.

Common Side Effects

  • Skin irritation at the application site
  • Redness or erythema
  • Itching or mild burning sensation
  • Headache
  • Gastrointestinal discomfort
  • Localised swelling

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Liver injury (hepatitis)
  • Kidney impairment or acute renal failure
  • Cardiovascular events such as myocardial infarction
  • Gastrointestinal ulceration or bleeding

Precautions & Warnings

When using Nurofen transdermal gel, consider the following safety measures.

  • NSAID hypersensitivity: avoid use in patients with known ibuprofen or NSAID allergy.
  • Active gastrointestinal ulcer: use with caution and monitor for bleeding.
  • Cardiovascular disease: assess risk and limit duration of therapy.
  • Pregnancy and lactation: avoid unless specifically advised by a healthcare professional.
  • Pediatric use: follow age‑appropriate dosing guidance and limit to recommended body areas.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct heat.

Avoid Interactions

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • ACE inhibitors (e.g., lisinopril): may reduce renal function.
  • Lithium: ibuprofen can raise lithium serum levels.
  • Methotrexate: risk of enhanced toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics (e.g., furosemide): possible renal impairment.
  • Antihypertensives (e.g., beta‑blockers): may blunt blood pressure control.
  • SSRIs (e.g., sertraline): increased bleeding tendency.
  • Oral hypoglycemics (e.g., sulfonylureas): potential alteration of glucose control.
  • Corticosteroids: additive risk of gastrointestinal ulceration.

Frequently Asked Questions

Nurofen is a topical ibuprofen product designed to relieve mild to moderate pain, lower fever, and reduce inflammation when applied to the skin. It is commonly used for headaches, muscle aches, joint discomfort, and minor swelling associated with injuries or arthritic conditions.

Ibuprofen in Nurofen works by blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for producing prostaglandins. By reducing prostaglandin levels, the medication diminishes pain signals, lowers body temperature, and lessens inflammation at the site of application.

The specific amount of Nurofen to apply is determined by the prescribing healthcare professional based on the condition being treated, the patient’s age, and the size of the affected area. Users should follow the instructions provided by their clinician or the product label.

The safety of topical ibuprofen during pregnancy or lactation has not been definitively established. It should only be used if a healthcare provider deems it necessary after weighing potential risks and benefits. Women who are pregnant or nursing should discuss alternatives with their doctor.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Nurofen delivers ibuprofen directly to the skin, providing localized relief with lower systemic exposure compared with oral tablets. This can reduce the risk of gastrointestinal side effects, but it may be less suitable for widespread pain that requires systemic treatment. Choice depends on the clinical situation and patient preference.

Store Nurofen at room temperature, ideally below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and ensure it is out of reach of children.

Nurofen is applied topically to clean, dry skin. A thin layer is spread over the affected area, gently massaged until absorbed, and the area is left uncovered unless otherwise directed. Do not apply to broken or irritated skin.

Serious risks include severe allergic reactions such as anaphylaxis, skin conditions like Stevens‑Johnson syndrome, liver injury, kidney impairment, cardiovascular events, and gastrointestinal ulceration or bleeding. Users should seek immediate medical attention if they experience symptoms such as rash, swelling, difficulty breathing, or unexplained abdominal pain.

Individuals with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, or those in the third trimester of pregnancy should avoid Nurofen unless advised otherwise by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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