Nurofen Minicaps (Ibuprofen)

Nurofen Minicaps contains ibuprofen, an NSAID that acts on inflammatory pathways to relieve discomfort.

• Headache: alleviates pain and pressure associated with tension or migraine onset.
• Dental pain: reduces pain following extractions or dental procedures.
• Musculoskeletal pain: eases aches from sprains, strains or minor arthritis.
• Fever: lowers elevated body temperature in febrile states.
• Menstrual discomfort: lessens cramping and lower‑back pain during periods.

• Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. By reducing prostaglandin levels, it dampens peripheral nociceptor sensitisation and lowers the hypothalamic set‑point for temperature regulation.

Adverse reactions to ibuprofen may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or mild abdominal pain.
• Headache: transient headache unrelated to the treated condition.
• Dizziness: light‑headed feeling, especially on standing.
• Rash: mild skin erythema or itching.
• Elevated blood pressure: modest rise in systolic/diastolic readings.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Severe skin reactions such as Stevens‑Johnson syndrome.
• Renal impairment or acute kidney injury.
• Hepatotoxicity: abnormal liver enzyme elevations.
• Anaphylaxis: rapid onset of hives, swelling and airway compromise.

When considering ibuprofen therapy, several safety measures are recommended.

• Assess renal function: evaluate baseline creatinine in patients with kidney disease.
• Monitor cardiovascular risk: use cautiously in individuals with hypertension or heart disease.
• Check gastrointestinal history: avoid in patients with active ulcers or bleeding disorders.
• Review concomitant medications: assess for other NSAIDs or anticoagulants.
• Pregnancy and lactation: limit use, especially in the third trimester.
• Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Ibuprofen can affect the activity of several other medicines, requiring attention to dosage and monitoring.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• High‑dose aspirin: heightened gastrointestinal toxicity.
• Selective COX‑2 inhibitors (e.g., celecoxib): additive renal and cardiovascular effects.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihypertensive efficacy.
• Diuretics: potential decline in renal perfusion.
• Lithium: ibuprofen may raise serum lithium levels.
• Methotrexate: reduced clearance leading to toxicity.
• Corticosteroids: increased risk of gastrointestinal ulceration.