Nurofen Plus (Ibuprofen, Codeine Phosphate Hemihydrate)

Ibuprofen blocks cyclooxygenase enzymes, lowering prostaglandin production and thereby reducing inflammation and pain at the site of injury. Codeine is converted to morphine in the body, which activates μ‑opioid receptors in the central nervous system, altering pain perception and providing additional analgesic effect.

The appropriate dose of Nurofen Plus is determined by a qualified prescriber based on the individual’s age, weight, medical condition, and response to therapy. Patients should follow the exact instructions provided on the prescription label and not adjust the dose on their own.

Safety data for ibuprofen and codeine during pregnancy are limited, and the combination is generally avoided, especially in the third trimester, due to potential risks to the fetus. While breastfeeding, codeine can pass into milk and may affect the infant. Consultation with a healthcare professional is essential before use.

To order Nurofen Plus, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with single‑ingredient ibuprofen, Nurofen Plus adds codeine, offering stronger pain relief for moderate pain that may not respond fully to NSAIDs alone. Unlike paracetamol, it provides anti‑inflammatory benefits from ibuprofen. However, the opioid component introduces additional safety considerations such as dependence and respiratory effects.

Nurofen Plus tablets should be stored at room temperature, below 25 °C, in their original packaging. Keep them away from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Nurofen Plus is taken orally as a tablet. The tablet should be swallowed whole with a full glass of water, preferably with food or after a meal to reduce gastrointestinal irritation. Do not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.

The most serious risks include respiratory depression, especially when combined with other CNS depressants, severe allergic reactions, gastrointestinal bleeding or ulceration from the ibuprofen component, liver injury, and the potential for dependence or addiction due to the codeine component.

Nurofen Plus should be avoided in individuals with known hypersensitivity to ibuprofen, codeine, or any excipients, those with severe respiratory disorders, uncontrolled asthma, significant liver or kidney impairment, and patients who are pregnant in the third trimester or breastfeeding without medical advice.