Product image of Nurofen Plus (Ibuprofen, Codeine Phosphate Hemihydrate) supplied by GNH India

Nurofen Plus

Active Ingredient:
Ibuprofen, Codeine Phosphate Hemihydrate
Origin:
EU

Nurofen Plus (Ibuprofen, Codeine Phosphate Hemihydrate)

Ibuprofen, the active ingredient in Nurofen Plus, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a combined tablet for oral use. It is formulated with codeine phosphate hemihydrate to provide analgesic and anti‑inflammatory effects for moderate pain in adults.

GNH India supplies Nurofen Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Reckitt Benckiser (Poland) S.A.

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Indications & Clinical Uses

Nurofen Plus combines an NSAID with an opioid, acting on inflammatory and nociceptive pathways to relieve moderate pain.

  • Dental pain: reduces pain and inflammation after dental procedures.
  • Musculoskeletal pain: alleviates pain from strains, sprains and backache.
  • Post‑operative pain: provides analgesia following minor surgery.
  • Dysmenorrhoea: eases menstrual cramps when other treatments are insufficient.
  • Acute injury pain: helps control pain from bruises or minor trauma.

How It Works

  • Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation and pain. Codeine phosphate hemihydrate is a pro‑drug that is metabolised to morphine, which binds to µ‑opioid receptors in the central nervous system, modulating pain perception and providing additional analgesia.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Constipation: reduced bowel movements.
  • Dizziness: transient light‑headedness.
  • Drowsiness: increased sleepiness.
  • Abdominal pain: discomfort in the stomach area.
  • Dry mouth: reduced saliva production.

Serious or Rare Side Effects

  • Respiratory depression: slowed breathing, especially with high opioid doses.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Gastrointestinal bleeding: vomiting blood or black stools.
  • Liver toxicity: elevated liver enzymes or jaundice.
  • Renal impairment: reduced kidney function.
  • Seizures: rare neurologic events.

Precautions & Warnings

Before using Nurofen Plus, consider the following safety measures.

  • Pregnancy: avoid unless clearly needed; discuss risks with a healthcare professional.
  • Breastfeeding: codeine may pass into milk; consult a doctor before use.
  • Liver disease: use with caution; monitor hepatic function.
  • Renal impairment: dose adjustment may be required.
  • Alcohol: limit intake as it can increase sedation and GI risk.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Nurofen Plus can interact with several medicines; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Other opioids: additive respiratory depression.
  • Benzodiazepines: enhanced sedation and CNS depression.
  • Anticoagulants (e.g., warfarin): increased risk of gastrointestinal bleeding.
  • MAO inhibitors: risk of severe hypotension.
  • CYP2D6 inhibitors: reduced conversion of codeine to morphine, decreasing analgesic effect.

Moderate Interactions (Monitor Closely)

  • SSRIs/SNRIs: potential for serotonin syndrome.
  • Diuretics: may reduce renal clearance of ibuprofen.
  • Antihypertensives: ibuprofen can blunt blood pressure control.
  • Antacids containing aluminum or magnesium: may affect absorption.
  • Lithium: ibuprofen can increase lithium levels.

Frequently Asked Questions

Nurofen Plus is indicated for the short‑term relief of moderate pain such as dental pain, musculoskeletal discomfort, postoperative pain, dysmenorrhoea and acute injury pain. It combines ibuprofen, an NSAID, with codeine phosphate hemihydrate, an opioid, to provide both anti‑inflammatory and analgesic effects.

Ibuprofen blocks cyclo‑oxygenase enzymes, lowering prostaglandin production and reducing inflammation and pain. Codeine phosphate hemihydrate is converted in the liver to morphine, which activates µ‑opioid receptors in the central nervous system, diminishing the perception of pain and providing additional relief.

The appropriate dose of Nurofen Plus is determined by the prescribing clinician based on the patient's age, weight, pain severity and medical history. Patients should follow the prescriber's instructions and never exceed the recommended amount.

Nurofen Plus should be used in pregnancy only if clearly needed and after consulting a healthcare professional, as both ibuprofen and codeine have potential risks. During breastfeeding, codeine can pass into milk; mothers should discuss safety with their doctor before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with ibuprofen alone, Nurofen Plus adds codeine, offering stronger analgesia for moderate pain that may not respond to NSAID monotherapy. Compared with stronger opioids, it provides a lower risk of severe dependence but still requires careful monitoring for opioid‑related side effects.

Store Nurofen Plus tablets at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure it is out of reach of children.

Nurofen Plus is taken orally with a full glass of water. It should be swallowed whole and not crushed or chewed. The tablet is intended for adult use unless otherwise directed by a healthcare professional.

Serious risks include respiratory depression, especially when combined with other CNS depressants, severe allergic reactions such as anaphylaxis, gastrointestinal bleeding, liver toxicity and renal impairment. Patients should seek immediate medical attention if they experience any of these symptoms.

Nurofen Plus should be avoided in individuals with known hypersensitivity to ibuprofen, codeine or any excipients, those with severe asthma triggered by NSAIDs, patients with significant liver or kidney disease, and anyone taking monoamine oxidase inhibitors. Pregnant women, breastfeeding mothers and children should only use it under strict medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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