Nurofen Pour Enfants Sans Sucre (Ibuprofen)

Ibuprofen acts as an analgesic and antipyretic by inhibiting cyclooxygenase enzymes involved in pain and fever pathways.

• Pain: Provides relief of mild to moderate pain such as headache, toothache, or musculoskeletal discomfort in children.
• Fever: Lowers elevated body temperature associated with infections or inflammatory conditions.
• Inflammation: Reduces swelling and discomfort caused by minor inflammatory processes.

• Ibuprofen exerts its effect through non‑selective inhibition of cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, blocking the conversion of arachidonic acid to prostaglandins. By decreasing prostaglandin synthesis, it reduces peripheral sensitization to pain, lowers the hypothalamic set‑point for temperature, and diminishes inflammatory mediators, resulting in analgesic, antipyretic, and anti‑inflammatory actions.

Ibuprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

• Stomach upset or abdominal discomfort
• Nausea
• Vomiting
• Diarrhea

Serious or Rare Side Effects

• Severe allergic reactions such as anaphylaxis
• Gastrointestinal bleeding or ulceration
• Kidney impairment or reduced renal function

When using ibuprofen in children, certain precautions should be observed.

• Dosage: follow prescriber instructions based on the child’s age and weight.
• Allergy: avoid use in children with known hypersensitivity to ibuprofen or other NSAIDs.
• Medical conditions: use with caution in children with asthma, kidney disease, liver disease, or bleeding disorders.
• Concomitant medications: do not combine with other NSAIDs, anticoagulants, or corticosteroids without medical advice.
• Pregnancy and lactation: consult a healthcare professional before use in pregnant or breastfeeding adolescents.
• Store at ambient temperature: keep the suspension in its original container, protect from moisture and direct sunlight.

Ibuprofen can interact with several medicines, requiring attention to avoid adverse effects.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Selective COX‑2 inhibitors: heightened cardiovascular risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or diuretics: possible reduction in renal function.
• Lithium: ibuprofen may raise lithium serum levels.
• Methotrexate: reduced clearance leading to toxicity.