Nurofen Ultra (Ibuprofen Lysine)

Nurofen Ultra contains ibuprofen lysine, an NSAID that acts on inflammatory pathways to alleviate pain and fever.

• Headache: provides relief from tension‑type and mild migraine headaches.
• Dental pain: reduces discomfort following dental procedures or toothache.
• Musculoskeletal pain: eases aches associated with strains, sprains and minor joint inflammation.
• Fever: lowers elevated body temperature in febrile conditions.
• Menstrual discomfort: helps lessen cramps and lower pelvic pain during menstruation.

• Ibuprofen lysine works primarily by inhibiting the cyclo‑oxygenase (COX) enzymes COX‑1 and COX‑2, which reduces the synthesis of prostaglandins involved in inflammation, pain signalling and fever generation. This enzymatic blockade diminishes peripheral sensitisation and central pain perception, providing analgesic and antipyretic effects.

Common Side Effects

• Gastrointestinal discomfort, such as dyspepsia or heartburn.
• Mild headache.
• Dizziness or light‑headedness.
• Nausea or occasional vomiting.
• Transient increase in blood pressure.
• Skin rash or mild itching.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Severe allergic reactions, including anaphylaxis.
• Hepatic or renal impairment.
• Cardiovascular events such as myocardial infarction or stroke.
• Severe skin reactions like Stevens‑Johnson syndrome.
• Blood dyscrasias such as thrombocytopenia.

Before using Nurofen Ultra, consider the following safety measures:

• Assess gastrointestinal risk: patients with a history of ulcers or bleeding should use caution.
• Evaluate cardiovascular status: individuals with heart disease should discuss use with a healthcare professional.
• Monitor renal function: avoid use in severe kidney impairment without medical advice.
• Check for drug allergies: discontinue if signs of hypersensitivity appear.
• Pregnancy and lactation: use only if clearly indicated and prescribed by a clinician.
• Store at ambient temperature: keep below 25°C, retain in original packaging, and protect from moisture.

Ibuprofen lysine can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened risk of bleeding.
• High‑dose aspirin or other NSAIDs: additive gastrointestinal toxicity.
• Selective COX‑2 inhibitors: increased cardiovascular risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in renal function.
• Diuretics: may enhance renal side effects.
• Lithium: ibuprofen may raise lithium serum levels.
• Methotrexate: potential for increased toxicity at high doses.