Nurofen Xpress (Ibuprofen Sodium)

Nurofen Xpress contains ibuprofen, an NSAID that acts on inflammatory pathways to relieve pain and fever.

• Headache: provides relief from tension‑type and mild migraine headaches.
• Dental pain: reduces discomfort following dental procedures or toothache.
• Musculoskeletal pain: eases aches of muscles, joints, and back.
• Fever: lowers elevated body temperature in febrile adults and children.
• Menstrual cramps: lessens cramp‑related pelvic pain.

• Ibuprofen sodium rapidly dissociates to ibuprofen, which reversibly inhibits cyclooxygenase‑1 and cyclo‑oxygenase‑2 enzymes. This inhibition lowers prostaglandin synthesis, decreasing inflammation, pain signalling, and fever generation at sites of tissue injury.

Adverse reactions to ibuprofen may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Dyspepsia: occasional stomach discomfort or heartburn.
• Nausea: feeling of queasiness.
• Headache: mild transient headache.
• Dizziness: light‑headed sensation.
• Rash: mild skin redness or itching.
• Edema: mild swelling of the ankles or feet.

Serious or Rare Side Effects

• Gastrointestinal bleeding: black or tarry stools, vomiting blood.
• Renal impairment: reduced urine output, swelling.
• Hepatotoxicity: jaundice, elevated liver enzymes.
• Anaphylaxis: severe allergic reaction with breathing difficulty.
• Stevens‑Johnson syndrome: severe skin blistering.
• Cardiovascular events: increased risk of heart attack or stroke.

When using Nurofen Xpress, consider the following safety measures:

• Contraindications: avoid if known allergy to ibuprofen or other NSAIDs.
• Gastrointestinal risk: use with food or antacids if prone to stomach irritation.
• Renal function: monitor kidney health in patients with existing renal disease.
• Cardiovascular caution: limit use in individuals with hypertension or heart disease.
• Pregnancy and lactation: consult healthcare professional before use.
• Store at ambient temperature: keep below 25°C, in original packaging, protected from moisture.

Ibuprofen may interact with several medicines; awareness helps prevent adverse events.

Major Interactions (Avoid)

• Anticoagulants: increased bleeding risk.
• High‑dose aspirin aspirin: heightened gastrointestinal toxicity.
• Selective COX‑2 inhibitors: additive renal toxicity.\nModerate Interactions (Monitor Closely):
• ACE inhibitors: possible reduction in antihypertensive effect.
• Diuretics: potential decrease in renal clearance.
• Lithium: increased serum lithium levels.
• Methotrexate: reduced renal elimination leading to toxicity.