Nurofen Xpress Minicaps (Ibuprofen)

Ibuprofen acts as an analgesic and antipyretic across several common painful and inflammatory conditions.

• Headache: provides relief from tension‑type and mild migraine headaches.
• Dental pain: reduces discomfort following dental procedures or toothache.
• Musculoskeletal pain: eases aches associated with back strain, sprains and minor joint inflammation.
• Fever: lowers elevated body temperature in febrile adults and children.
• Menstrual discomfort: lessens cramps and lower‑back pain linked to menstruation.

• Ibuprofen inhibits the cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostagmines that mediate inflammation, pain and fever. By reducing prostaglandin levels, it dampens peripheral nociceptor sensitisation and lowers the hypothalamic set‑point for body temperature.

Adverse reactions to ibuprofen may range from mild to severe and are reported with oral NSAID use.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia or mild abdominal pain.
• Headache: transient headache not related to the condition being treated.
• Dizziness: light‑headed feeling, especially when standing quickly.
• Rash: mild skin redness or itching.
• Elevated blood pressure: modest rise in systolic/diastolic readings.

Serious or Rare Side Effects

• Gastrointestinal bleeding: black or tarry stools, vomiting blood.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Renal impairment: reduced urine output or swelling of the limbs.
• Hepatotoxicity: jaundice or abnormal liver function tests.
• Anaphylaxis: sudden difficulty breathing, swelling of the face or throat.

When using ibuprofen, consider the following safety measures:

• Assess the risk of gastro‑intestinal ulceration or bleeding in high‑risk patients.
• Avoid use in patients with known hypersensitivity to NSAIDs.
• Monitor renal function in those with pre‑existing kidney disease.
• Use caution when co‑administered with antihypertensive or diuretic medications to prevent fluid‑retention effects.
• Store at below 25°C: keep in the original pack and protect from moisture.

Ibuprofen may interact with several drug classes; monitoring is advised.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding – avoid concurrent use.
• High‑dose aspirin or other NSAIDs: additive gastrointestinal toxicity.
• Selective COX‑2 inhibitors (e.g., celecoxib): heightened cardiovascular risk.

Moderate Interactions (Monitor Closely):

• ACE‑inhibitors and ARBs: may reduce antihypertensive efficacy and affect renal function.
• Diuretics (e.g., furosemide): potential for reduced renal perfusion.
• Lithium: ibuprofen can raise serum lithium levels, requiring monitoring.
• Methotrexate: may increase methotrexate toxicity.
• Corticophyll ‑ c   ---  --- ---