Product image of Nurofenbaby Prima Infanzia (Ibuprofen) supplied by GNH India

Nurofenbaby Prima Infanzia

Active Ingredient:
Ibuprofen
Origin:
EU

Nurofenbaby Prima Infanzia (Ibuprofen)

Ibuprofen, the active ingredient in Nurofenbaby Prima Infanzia, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a rectal suppository. It delivers analgesic and antipyretic activity, helping to alleviate mild to moderate pain and lower elevated body temperature in infants and young children. It is formulated for safe and convenient administration in the pediatric population.

GNH India supplies Nurofenbaby Prima Infanzia as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics across global markets while adhering to quality standards and regulatory requirements. The company ensures reliable logistics and documentation for international trade.

Manufacturer / TM Owner

Reckitt Benckiser Healthcare (Italia) Spa

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Indications & Clinical Uses

Ibuprofen acts as an NSAID to reduce inflammation, pain and fever in the pediatric population.

  • Pain relief: alleviates mild to moderate pain associated with common childhood ailments.
  • Fever reduction: lowers elevated body temperature in infants and toddlers.
  • Inflammatory discomfort: reduces discomfort from minor inflammatory conditions such as teething or mild musculoskeletal strain.

How It Works

  • Ibuprofen inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. By lowering prostaglandin synthesis, it reduces peripheral sensitization of nociceptors and the hypothalamic set‑point for temperature, resulting in analgesic, antipyretic and anti‑inflammatory effects. The suppression of prostaglandin E2 in the central nervous system contributes to the antipyretic action, while reduced prostaglandin levels in inflamed tissues diminish edema and pain signaling.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, abdominal pain or mild dyspepsia.
  • Diarrhea or constipation: changes in bowel habits.
  • Local irritation: mild redness or irritation at the rectal site.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, bronchospasm or anaphylaxis.
  • Gastrointestinal bleeding or ulcer: black stools or vomiting blood.
  • Renal impairment: reduced urine output or kidney dysfunction.

Precautions & Warnings

When using ibuprofen suppositories in infants, several safety considerations should be observed.

  • Age restriction: use only in children for whom the product is indicated, typically under 12 months as directed by a healthcare professional.
  • Dosage supervision: dosing must be determined by a qualified prescriber based on weight and age.
  • Dehydration risk: avoid use in children who are dehydrated or have fluid loss without medical advice.
  • Renal or hepatic impairment: use with caution in patients with known kidney or liver disease.
  • Allergic history: discontinue if signs of hypersensitivity such as rash or swelling appear.
  • Store at room temperature: keep the suppositories in the original packaging, protect from moisture and heat.

Avoid Interactions

Ibuprofen can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • ACE inhibitors or ARBs: potential reduction in renal function.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: may raise ulcer risk.
  • Methotrexate: possible enhanced toxicity.

Frequently Asked Questions

Nurofenbaby Prima Infanzia is a pediatric ibuprofen suppository designed to provide analgesic and antipyretic effects. It is used to relieve mild to moderate pain and to lower fever in infants and young children when oral administration is not feasible or preferred.

Ibuprofen works by inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for the production of prostaglandins. Reduced prostaglandin levels decrease inflammation, lower the hypothalamic set‑point for temperature, and diminish pain signaling, resulting in analgesic, antipyretic, and anti‑inflammatory actions.

The appropriate dose of Nurofenbaby Prima Infanzia is determined by a qualified healthcare professional based on the child’s age, weight, and clinical condition. The prescriber will select the correct suppository strength and frequency to ensure safe and effective therapy.

The safety of ibuprofen during pregnancy or lactation depends on the trimester and individual circumstances. Generally, ibuprofen is avoided in the third trimester of pregnancy and used with caution while breastfeeding. Healthcare providers should evaluate risks and benefits before recommending its use in these situations.

To order Nurofenbaby Prima Infanzia, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Nurofenbaby delivers ibuprofen via a rectal suppository, offering an alternative to oral acetaminophen or liquid ibuprofen formulations. Its rectal route can be advantageous when oral intake is difficult, and ibuprofen provides longer‑lasting antipyretic and anti‑inflammatory effects compared with acetaminophen, though both are considered safe when used as directed.

Nurofenbaby suppositories should be stored at room temperature, ideally below 25 °C, in their original packaging to protect from moisture and heat. Keep the product out of reach of children and avoid exposure to direct sunlight or excessive humidity, which could affect the integrity of the suppository.

The suppository is inserted rectally, preferably after a bowel movement, using a gloved finger or an applicator if provided. The child should be placed in a comfortable position, such as lying on their side with knees drawn toward the chest, to ensure proper placement and absorption.

Serious risks include severe allergic reactions (anaphylaxis), gastrointestinal bleeding or ulceration, and renal impairment, especially in dehydrated or medically compromised children. Prompt medical attention is required if symptoms such as rash, swelling, vomiting blood, black stools, or reduced urine output occur.

Children with known hypersensitivity to ibuprofen or any NSAID, those with active gastrointestinal bleeding, severe renal or hepatic disease, or those who have experienced a previous severe reaction to ibuprofen should avoid using Nurofenbaby. Additionally, it should not be given to infants outside the age range specified by the prescriber.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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