Product image of Nutrineal 4 Amino Acids (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Nutrineal 4 Amino Acids

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Nutrineal 4 Amino Acids (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin, the active ingredients in Nutrineal 4 Amino Acids, are essential amino acids presented as a sterile parenteral solution for intraperitoneal use. It supplies the building blocks needed for protein synthesis in patients who cannot receive enteral nutrition.

GNH India supplies Nutrineal 4 Amino Acids as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and transplant centres worldwide. The company adheres to EU manufacturing standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Nutrineal 4 Amino Acids is used in parenteral nutrition to address protein and amino acid requirements in several clinical situations.

  • Total Parenteral Nutrition (TPN): provides essential amino acids for patients unable to receive enteral feeding.
  • Peritoneal Dialysis Support: supplements protein loss associated with continuous ambulatory peritoneal dialysis.
  • Critical Care Management: helps maintain nitrogen balance in severely ill or postoperative patients.

How It Works

  • Each amino acid in Nutrineal 4 Amino Acids is directly available for cellular uptake after intraperitoneal administration. The solution diffuses into the peritoneal capillary network, where amino acids enter the bloodstream and participate in protein synthesis, gluconeogenesis, and other metabolic pathways. By supplying essential and non‑essential amino acids, the formulation supports tissue repair, immune function, and overall nitrogen balance in patients lacking adequate nutritional intake.

Side Effects

Like other parenteral amino acid preparations, Nutrineal 4 Amino Acids may be associated with adverse reactions.

Common Side Effects

  • Hyperglycemia: elevated blood glucose levels, especially in diabetic patients.
  • Electrolyte disturbances: shifts in potassium, sodium, or calcium levels.
  • Mild abdominal discomfort: transient pain at the injection site.
  • Nausea or vomiting: gastrointestinal upset following infusion.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical intervention.
  • Metabolic acidosis: significant pH imbalance due to amino acid metabolism.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Sepsis: infection related to catheter or infusion system.

Precautions & Warnings

Prior to using Nutrineal 4 Amino Acids, clinicians should consider the following precautions.

  • Renal function: assess kidney performance to avoid nitrogen overload.
  • Hepatic status: monitor liver enzymes in patients with pre‑existing liver disease.
  • Fluid balance: adjust infusion volume to prevent fluid overload.
  • Electrolyte monitoring: regularly check serum electrolytes during therapy.
  • Catheter care: maintain aseptic technique to reduce infection risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Nutrineal 4 Amino Acids can interact with other therapies; awareness of these interactions helps ensure safe use.

Major Interactions (Avoid)

  • High‑dose protein supplements: may cause excessive nitrogen load and renal strain.
  • Certain chemotherapeutic agents (e.g., methotrexate): can alter amino acid metabolism and increase toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate electrolyte shifts when combined with amino acid infusion.
  • Insulin therapy: amino acids can affect glucose metabolism, requiring dose adjustments.
  • Antiepileptic drugs (e.g., valproate): potential for altered plasma amino acid levels.

Frequently Asked Questions

Nutrineal 4 Amino Acids is a sterile amino acid solution administered intraperitoneally to provide essential and non‑essential amino acids for patients who cannot receive nutrition through the gastrointestinal tract. It is commonly employed as part of parenteral nutrition regimens to support protein synthesis, maintain nitrogen balance, and aid recovery in critically ill or postoperative patients.

After intraperitoneal injection, the amino acids diffuse across the peritoneal membrane into the systemic circulation. Once in the bloodstream, they become substrates for cellular processes such as protein synthesis, gluconeogenesis, and enzyme production. By directly supplying these building blocks, the mixture helps meet metabolic demands when oral or enteral intake is insufficient.

The prescribed dose of Nutrineal 4 Amino Acids is individualized by the treating clinician based on factors such as the patient’s weight, nutritional status, renal and hepatic function, and overall clinical condition. Healthcare professionals calculate the appropriate amount to achieve targeted amino acid delivery while avoiding excess nitrogen load.

Safety data for Nutrineal 4 Amino Acids in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians must evaluate each case carefully and consider alternative nutritional strategies when appropriate.

To place an order, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including cold‑chain handling if needed) and assists with import documentation.

Nutrineal 4 Amino Acids is a comprehensive amino acid formulation designed for intraperitoneal delivery, whereas many alternative products are formulated for intravenous use. Its composition includes a balanced mix of essential and non‑essential amino acids, making it suitable for patients requiring broad-spectrum protein support. Choice of product depends on the clinical route, compatibility with other nutrition components, and institutional protocols.

The solution should be stored at 2‑8 °C (refrigerated). Keep the container in its original packaging, protect it from light, and avoid freezing or shaking. Maintaining the cold‑chain ensures stability of the amino acids and prevents degradation before administration.

Nutrineal 4 Amino Acids is administered via intraperitoneal injection, typically through a peritoneal catheter. The healthcare provider prepares the sterile solution according to aseptic technique, selects the appropriate volume based on the prescribed dose, and infuses it slowly to allow absorption across the peritoneal membrane.

Serious risks include anaphylactic reactions, metabolic acidosis, hepatic dysfunction, and catheter‑related infections such as sepsis. Patients with compromised renal or hepatic function are at higher risk for nitrogen overload and electrolyte disturbances. Continuous monitoring and prompt management of adverse events are essential during therapy.

Nutrineal 4 Amino Acids should be avoided in individuals with known hypersensitivity to any of its amino acid components, severe renal or hepatic impairment where nitrogen clearance is compromised, and in patients with uncontrolled metabolic disorders that could be exacerbated by amino acid infusion. Clinical judgment is required to assess suitability for each patient.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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