Product image of Nutrineal Peritoneal Dialysis 4 (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Nutrineal Peritoneal Dialysis 4

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Nutrineal Peritoneal Dialysis 4 (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin, the active ingredient in Nutrineal Peritoneal Dialysis 4, is a mixture of essential and non‑essential amino acids presented as a sterile solution for peritoneal dialysis use. It is used to provide nutritional support to patients undergoing chronic peritoneal dialysis.

GNH India supplies Nutrineal Peritoneal Dialysis 4 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and dialysis centres worldwide.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Nutrineal Peritoneal Dialysis 4 supplies amino acids directly to the peritoneal cavity, supporting patients with renal failure undergoing peritoneal dialysis.

  • Chronic kidney disease (CKD) on peritoneal dialysis: helps maintain nitrogen balance and protein synthesis.
  • Acute kidney injury (AKI) requiring peritoneal dialysis: provides essential amino acids while fluid removal is ongoing.
  • Nutritional supplementation for peritoneal dialysis patients: improves overall caloric and protein intake when oral intake is insufficient.

How It Works

  • The solution delivers a balanced profile of essential and non‑essential amino acids across the peritoneal membrane into the bloodstream. These amino acids are absorbed and become substrates for protein synthesis, helping to preserve lean body mass and counteract the catabolic state associated with renal failure and dialysis.

Side Effects

Nutrineal Peritoneal Dialysis 4 may be associated with local and systemic reactions typical of peritoneal dialysis solutions.

Common Side Effects

  • Abdominal discomfort: mild cramping or bloating during exchanges.
  • Transient hyperglycaemia: slight rise in blood glucose due to amino‑acid metabolism.
  • Peritoneal irritation: mild erythema or tenderness at the catheter site.
  • Nausea: occasional feeling of queasiness during or after infusion.
  • Electrolyte shift: minor changes in serum potassium or sodium levels.

Serious or Rare Side Effects

  • Peritonitis: infection of the peritoneal cavity requiring prompt medical treatment.
  • Severe allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Metabolic acidosis: significant drop in blood pH linked to amino‑acid catabolism.
  • Hyperosmolar volume overload: fluid accumulation leading to pulmonary edema.
  • Persistent hypotension: sustained low blood pressure during exchanges.

Precautions & Warnings

When using Nutrineal Peritoneal Dialysis 4, clinicians should assess patient suitability and monitor relevant clinical parameters.

  • Assess nutritional status: evaluate baseline protein and calorie needs before initiation.
  • Monitor laboratory values: regularly check serum electrolytes, urea, and albumin levels.
  • Adjust dialysis prescription: modify dwell time or volume if fluid balance concerns arise.
  • Observe for infection signs: watch for fever, abdominal pain, or cloudy effluent indicating peritonitis.
  • Review medication interactions: consider concurrent drugs that affect electrolyte balance.
  • Store at ambient temperature: keep in the original packaging, protect from direct sunlight and moisture.

Avoid Interactions

Nutrineal Peritoneal Dialysis 4 can interact with other therapies that influence fluid, electrolyte, or metabolic balance.

Major Interactions (Avoid)

  • High‑dose potassium supplements: may exacerbate hyperkalaemia when combined with amino‑acid solutions.
  • Sodium‑rich intravenous fluids: increase risk of volume overload and hypertension.

Moderate Interactions (Monitor Closely)

  • Insulin or oral hypoglycaemic agents: amino‑acid metabolism can affect glucose control.
  • Loop diuretics: may amplify electrolyte shifts, requiring closer monitoring.
  • ACE inhibitors or ARBs: combined effect on renal haemodynamics warrants observation.
  • Anticoagulants: peritoneal irritation can alter bleeding risk, especially with catheter manipulation.

Frequently Asked Questions

Nutrineal Peritoneal Dialysis 4 is an amino‑acid based dialysis solution designed to provide nutritional support to patients receiving chronic or acute peritoneal dialysis. It helps maintain protein balance and supplies essential amino acids that may be lacking due to reduced oral intake or dialysis‑related losses.

The amino acids in Nutrineal cross the peritoneal membrane during the dwell phase and are absorbed into the bloodstream. Once in circulation, they serve as building blocks for protein synthesis, supporting lean body mass and counteracting the catabolic effects of renal failure and dialysis.

The prescribed volume and frequency of Nutrineal are determined by the treating nephrologist based on the patient’s dialysis regimen, nutritional status, and fluid balance. Clinicians tailor the prescription to individual needs rather than using a fixed standard dose.

Safety data for amino‑acid dialysis solutions in pregnancy and lactation are limited. Use is generally reserved for situations where the benefit to the mother outweighs potential risks to the fetus or infant, and it should be decided by a specialist physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Unlike glucose‑based fluids, Nutrineal supplies amino acids instead of carbohydrate calories, reducing glucose load and offering direct protein nutrition. This can be advantageous for patients with poor glycaemic control or those needing additional protein, though it may require careful monitoring of nitrogen balance and acid‑base status.

Nutrineal should be stored at ambient temperature, protected from direct sunlight and moisture, and kept in its original sealed container until use. Once opened, the solution should be used according to the manufacturer’s aseptic guidelines and discarded after the recommended dwell period.

The solution is introduced into the peritoneal cavity through the dialysis catheter as part of a standard exchange. It follows the same aseptic technique as other peritoneal dialysis fluids, with dwell times and volumes adjusted by the treating clinician.

Serious risks include peritonitis, severe allergic reactions, metabolic acidosis, and fluid overload leading to pulmonary edema. Prompt recognition of symptoms such as fever, abdominal pain, rash, or sudden shortness of breath is essential for immediate medical intervention.

Patients with known hypersensitivity to any component of the amino‑acid solution, active peritoneal infection, uncontrolled electrolyte disturbances, or severe fluid overload should not receive Nutrineal unless a specialist determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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