Product image of Nystamysyn (Nystatin) supplied by GNH India

Nystamysyn

Active Ingredient:
Nystatin
Origin:
EU

Nystamysyn (Nystatin)

Nystatin, the active ingredient in Nystamysyn, is an antifungal polyol polyfungal polyphenol presented as a topical formulation for cutaneous and mucosal use. It treats superficial fungal infections such as candidiasis in infants, children, and adults.

GNH India supplies Nystamysyn as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Manufacturer / TM Owner

Farmasyn S.A.

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Indications & Clinical Uses

Nystamysyn is an antifungal agent that acts on yeast and mold species causing mucocutaneous infections.

  • Oral thrush (candidiasis): Reduces fungal load and alleviates symptoms such as soreness.
  • Esophageal candidiasis: Helps clear infection and improve swallowing comfort.
  • Dermal candidiasis: Controls skin colonisation and promotes healing.
  • Vaginal candidiasis: Restores normal flora and reduces discharge and itching.

How It Works

  • Nystatin binds to ergosterol in fungal cell membranes, creating pores that increase membrane permeability. This leads to leakage of intracellular electrolytes and macromolecules, ultimately causing fungal cell death without significant toxicity to human cells that lack ergosterol.

Side Effects

Nystamysyn may elicit adverse reactions that vary in frequency and severity.

Common Side Effects

  • Mild gastrointestinal upset: Nausea or stomach discomfort.
  • Local irritation: Burning or itching at the application site.
  • Rash: Minor skin erythema.
  • Taste alteration: Temporary dysgeusia.

Serious or Rare Side Effects

  • Severe allergic reaction: Hives, swelling, or anaphylaxis.
  • Hepatotoxicity: Elevated liver enzymes indicating liver stress.
  • Renal impairment: Changes in kidney function tests.
  • Persistent diarrhea: Prolonged watery stools indicating possible infection spread.

Precautions & Warnings

Before prescribing Nystamysyn, clinicians should consider several safety aspects.

  • Renal function: Assess renal clearance as nystatin is excreted unchanged.
  • Hepatic function: Monitor liver enzymes in patients with pre‑existing liver disease.
  • Pregnancy: Use only if clearly needed; limited data suggest caution.
  • Breastfeeding: Evaluate risk‑benefit as small amounts may pass into milk.
  • Concomitant antibiotics: Watch for overgrowth of resistant organisms.
  • Store at below 25°C: Keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nystamysyn has a limited interaction profile, but certain combinations require attention.

Major Interactions (Avoid)

  • Systemic azoles: Concurrent use may reduce nystatin efficacy.
  • Live‑vaccines: May increase risk of fungal infection when immune response is suppressed.

Moderate Interactions (Monitor Closely):\n- Broad‑spectrum antibiotics: May alter normal flora and predispose to fungal overgrowth.

  • Immunosuppressants: May require dose adjustment of antifungal therapy.
  • Proton‑pump inhibitors: May affect gastric pH and drug dissolution.
  • Antacids: May reduce local availability of the drug in the GI tract.

Frequently Asked Questions

Nystamysyn contains nystatin, an antifungal medication used to treat superficial yeast infections such as oral thrush, esophageal candidiasis, skin candidiasis and vaginal d​.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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