Product image of Nystan (Nystatin) supplied by GNH India

Nystan

Active Ingredient:
Nystatin
Origin:
EU

Nystan (Nystatin)

Nystatin, the active ingredient in Nystan, is a polyol polyene antifungal presented as an oral formulation for oral use. It treats Candida infections of the mouth, throat, gastrointestinal tract and skin in patients of all ages.
GNH India supplies Nystan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vygoris Limited

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Indications & Clinical Uses

Nystatin is used to manage fungal infections caused by Candida species affecting the mucosal and gastrointestinal pathways.

  • Oral thrush (candidiasis): reduces fungal load and relieves symptoms in the oral cavity.
  • Esophageal candidiasis: provides local antifungal effect to clear infection.
  • Gastrointestinal candidiasis: treats overgrowth and associated discomfort.
  • Cutaneous candidiasis (e.g., diaper rash): controls fungal growth on skin.

How It Works

  • Nystatin binds to ergosterol, a key component of fungal cell membranes, forming pores that increase membrane permeability. This leads to leakage of intracellular electrolytes and macromolecules, ultimately causing cell death or inhibition of fungal growth, particularly against Candida species.

Side Effects

Nystatin may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild stomach upset after oral administration.
  • Vomiting: occasional expulsion of stomach contents.
  • Diarrhea: loose stools during treatment.
  • Abdominal cramps: transient discomfort.
  • Taste alteration: temporary change in flavor perception.
  • Mild skin irritation: localized rash at mucosal sites.

Serious or Rare Side Effects

  • Allergic reaction: rash, urticaria, or anaphylaxis.
  • Hepatotoxicity: signs of liver dysfunction.
  • Severe colitis: persistent abdominal pain and bloody stools.
  • Renal impairment: decreased kidney function.
  • Hemolysis: breakdown of red blood cells.
  • Hypersensitivity pneumonitis: respiratory distress.

Precautions & Warnings

Before using Nystan, consider the following safety measures.

  • Renal impairment: monitor kidney function during therapy.
  • Hepatic disease: use with caution in patients with liver disorders.
  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: evaluate risk versus benefit with a physician.
  • Concomitant medications: review all drugs for potential interactions.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nystan may interact with other medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid)

  • Nephrotoxic agents (e.g., aminoglycosides): increased risk of renal toxicity.
  • Systemic antifungals (e.g., amphotericin B): additive toxicity and overlapping side effects.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium: may reduce Nystatin absorption.
  • Oral contraceptives: possible reduction in efficacy.
  • Proton pump inhibitors: altered gastric pH may affect drug activity.

Frequently Asked Questions

Nystan contains Nystatin, an antifungal agent used to treat infections caused by Candida species. It is commonly prescribed for oral thrush, esophageal candidiasis, gastrointestinal candidiasis, and certain skin infections such as diaper rash.

Nystatin binds to ergosterol in fungal cell membranes, creating pores that increase permeability. This disrupts essential ion balance and leads to leakage of cellular contents, ultimately inhibiting fungal growth or causing cell death.

The dosage of Nystan is individualized and set by the prescribing healthcare professional based on the type and severity of the infection, patient age, weight, and renal or hepatic function. Patients should follow the prescriber’s instructions precisely.

Nystan should be used during pregnancy or while breastfeeding only if clearly needed and after consulting a qualified healthcare provider. The benefits must outweigh any potential risks to the fetus or infant, and the prescriber will determine suitability.

To order Nystan, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to Nystan is the azole class, such as fluconazole, which is systemically absorbed and works by inhibiting fungal enzyme synthesis. Nystatin acts locally, has minimal systemic absorption, and is preferred for superficial or mucosal Candida infections where systemic exposure is not required.

Nystan should be stored below 25 °C in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme temperatures, which could affect its stability and efficacy.

Nystan is administered orally. The suspension is usually measured with a calibrated spoon or syringe, then swallowed or held in the mouth and swished before swallowing, depending on the specific indication and prescriber’s instructions.

Serious risks include allergic reactions such as rash, urticaria or anaphylaxis, hepatotoxicity, severe colitis, and renal impairment. Patients should seek immediate medical attention if they experience symptoms like difficulty breathing, jaundice, persistent abdominal pain, or reduced urine output.

Nystan is contraindicated in individuals with a known hypersensitivity to Nystatin or any component of the formulation. Caution is also advised for patients with severe renal or hepatic dysfunction, and it should be avoided in those for whom an alternative therapy is more appropriate.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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