Nystan (Ready-Mixed) (Nystatin)

Nystan (Ready‑Mixed) is an antifungal agent that acts on yeast‑type fungi causing mucocutaneous infections.

• Oral candidiasis: reduces fungal colonisation and alleviates symptoms in the mouth and throat.
• Oropharyngeal thrush: clears Candida plaques and prevents recurrence in immunocompromised patients.
• Esophageal candidiasis: assists in symptom relief and fungal eradication when administered as a swish‑and‑spit preparation.
• Dermal candidiasis: treats skin‑fold and intertriginous Candida infections.
• Vaginal candidiasis: helps restore normal vaginal flora by reducing Candida overgrowth.

• Nystatin binds to sterols, primarily ergosterol, in the fungal cell membrane, creating pores that increase membrane permeability. This leads to leakage of intracellular electrolytes and macromolecules, ultimately causing cell death. The selective affinity for fungal sterols over mammalian cholesterol provides a high degree of topical safety.

Nystan (Ready‑Mixed) may cause local or systemic reactions, most of which are mild and reversible.

Common Side Effects

• Mild burning or stinging at the application site.
• Transient oral irritation.
• Nausea when swallowed in larger amounts.
• Diarrhoea.
• Skin erythema at the site of topical use.

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis) with rash, swelling, or difficulty breathing.
• Persistent vomiting.
• Hepatotoxicity in rare, prolonged systemic exposure.
• Stevens‑Johnson syndrome.
• Significant electrolyte imbalance from extensive mucosal absorption.

When using Nystan (Ready‑Mixed), consider the following safety measures:

• Assess patient history: verify any known hypersensitivity to nystatin or polyol antifungals.
• Monitor renal function: patients with renal impairment may require dose adjustment.
• Avoid use in infants under 2 months unless directly prescribed by a clinician.
• Caution for pregnancy or breast‑feeding women if the treatment is systemic or extensive ‑ consult a health‑care professional.
• Store at below 25°C: keep the ready‑mixed suspension in the original pack or container and protect from moist the  

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