Nystatin Acis (Nystatin)

Nystatin Acis is an antifungal agent used to manage infections caused by susceptible Candida species.

• Oral thrush: reduces fungal load and relieves symptoms in the mouth and throat.
• Esophageal candidiasis: helps clear infection and improve swallowing.
• Cutaneous candidiasis: treats skin fungal infections such as diaper rash and intertrigo.
• Intestinal candidiasis: controls overgrowth of Candida in the gastrointestinal tract.
• Prophylaxis in immunocompromised patients: prevents fungal colonisation during high‑risk periods.

• Nystatin binds to ergosterol, a key component of fungal cell membranes, forming pores that increase membrane permeability. This leads to leakage of intracellular electrolytes and macromolecules, ultimately causing fungal cell death without significant activity against human cells.

Nystatin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

• Nausea: mild stomach upset after oral administration.
• Vomiting: occasional expulsion of stomach contents.
• Abdominal cramps: transient discomfort in the abdomen.
• Diarrhea: loose stools during treatment.
• Skin rash: localized redness or irritation.
• Itching: mild pruritus at the application site.

Serious or Rare Side Effects

• Anaphylactic reaction: severe allergic response requiring immediate medical attention.
• Hepatotoxicity: signs of liver injury such as jaundice.
• Nephrotoxicity: impaired kidney function, especially with high doses.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Persistent gastrointestinal upset: prolonged vomiting or diarrhea.
• Hematologic abnormalities: rare blood cell count changes.

When using Nystatin Acis, consider the following safety measures.

• Pregnancy: use only if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding: caution advised as small amounts may be excreted in breast milk.
• Renal impairment: monitor kidney function and adjust therapy if needed.
• Hepatic impairment: assess liver function before and during treatment.
• Drug interactions: review concomitant medications for possible interactions.
• Store at ambient temperature: keep in the original packaging, protect from moisture and light.

Nystatin Acis may interact with other medicines; some interactions require avoidance while others need monitoring.

Major Interactions (Avoid)

• Concurrent nephrotoxic drugs: increased risk of kidney injury.
• Co‑administration with other polyene antifungals: heightened toxicity potential.
• Systemic corticosteroids: may reduce antifungal efficacy.

Moderate Interactions (Monitor Closely)

• Antacids: may affect oral absorption of the drug.
• Broad‑spectrum antibiotics: can alter normal flora and affect fungal balance.
• Oral contraceptives: possible reduction in contraceptive effectiveness.