Nystatin Tzf (Nystatin)

Nystatin Tzf is used to manage Candida infections affecting epithelial surfaces.

• Oral thrush: eradicates Candida albicans from the oral mucosa, reducing plaques and discomfort.
• Diaper dermatitis: clears cutaneous candidiasis in infants, relieving erythema and maceration.
• Intertriginous candidiasis: treats fungal overgrowth in skin folds, improving redness and itching.
• Esophageal candidiasis (topical swallow): controls Candida lesions in the esophagus, aiding symptom relief.
• Prophylaxis in immunocompromised patients: prevents colonisation of Candida on mucosal surfaces.

• Nystatin binds to ergosterol, a key sterol in fungal cell membranes, forming pores that increase membrane permeability. This leads to leakage of intracellular electrolytes and macromolecules, ultimately causing fungal cell death without significant systemic absorption.

Nystatin Tzf may cause local and systemic adverse reactions.

Common Side Effects

• Burning sensation at application site: mild transient discomfort.
• Pruritus: itching of the treated area.
• Erythema: redness of the skin or mucosa.
• Dryness: localized dryness or flaking.
• Nausea (if swallowed): mild gastrointestinal upset.

Serious or Rare Side Effects

• Allergic reaction: urticaria, angioedema, or anaphylaxis.
• Severe dermatitis: extensive skin irritation or contact dermatitis.
• Hepatotoxicity: rare liver enzyme elevation with extensive use.
• Systemic absorption leading to gastrointestinal cramps or diarrhea.

Before using Nystatin Tzf, consider the following safety measures.

• Hypersensitivity: avoid if known allergy to nystatin or formulation excipients.
• Extensive application: limit use to affected areas; avoid large body surface coverage.
• Ocular exposure: keep product away from eyes; rinse with water if contact occurs.
• Pregnancy and lactation: use only if clearly needed and prescribed by a healthcare professional.
• Concomitant skin conditions: monitor for increased irritation when used on compromised skin.
• Store at below 25°C: keep in original container, protect from moisture and direct sunlight.

Nystatin Tzf has limited systemic absorption, yet certain combinations require attention.

Major Interactions (Avoid)

• Concurrent topical antifungals: may increase local irritation or reduce efficacy.
• Systemic corticosteroids applied to same area: heightened risk of skin atrophy.

Moderate Interactions (Monitor Closely)

• Broad‑spectrum antibiotics: may alter normal flora, potentially affecting Candida colonisation patterns.
• Antacids or sucralfate (if oral suspension): could affect mucosal coating and drug contact time.
• Other topical agents containing alcohol or harsh solvents: may exacerbate dryness or irritation.