Nystatyna Teva (Nystatin)

Nystatin is a polyene antifungal that acts on Candida species affecting the oral and upper gastrointestinal tract.

• Oral candidiasis (thrush): reduces fungal load and relieves symptoms in patients with mouth Candida infection.
• Esophageal candidiasis: clears Candida from the esophagus, improving swallowing and reducing pain.
• Denture‑related stomatitis: eliminates Candida overgrowth on denture surfaces, helping resolve inflammation.

• Nystatin binds to ergosterol, a key sterol component of fungal cell membranes. This interaction creates pores that increase membrane permeability, leading to leakage of intracellular contents and ultimately causing fungal cell death without significant absorption into human tissues.

Nystatin may cause adverse reactions, most of which are mild and limited to the gastrointestinal tract or skin.

Common Side Effects

• Nausea: mild discomfort in the stomach after oral administration.
• Vomiting: occasional expulsion of stomach contents.
• Diarrhea: loose stools occurring during treatment.
• Abdominal pain: cramping or discomfort in the abdomen.
• Altered taste: temporary change in taste perception.
• Mild rash: skin redness or itching at the site of contact.

Serious or Rare Side Effects

• Severe allergic reaction: anaphylaxis with difficulty breathing, swelling, or hives.
• Hepatotoxicity: rare liver enzyme elevation requiring monitoring.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Persistent vomiting: leading to dehydration or electrolyte imbalance.
• Rare neutropenia: significant drop in white blood cells.
• Unexplained fever: may indicate systemic infection.

Before using Nystatyna Teva, consider the following safety measures.

• Pregnancy: consult a healthcare professional; safety data are limited.
• Breastfeeding: discuss potential risks with a physician.
• Renal impairment: use with caution as excretion may be reduced.
• Known hypersensitivity: avoid if allergic to nystatin or other polyenes.
• Concomitant medications: review all drugs to identify potential interactions.
• Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Nystatyna Teva has a low potential for drug‑drug interactions, but certain combinations warrant attention.

Major Interactions (Avoid)

• None reported: no clinically significant major interactions have been identified.

Moderate Interactions (Monitor Closely)

• Oral antibiotics: may alter gut flora and affect Candida balance.
• Other antifungal agents: monitor for additive gastrointestinal irritation.
• Antacids: could affect dissolution and absorption of the oral formulation.
• Probiotics: may reduce antifungal efficacy, requiring clinical observation.
• Immunosuppressants: increased risk of opportunistic infections; monitor patient closely.