Nystatyna Vp (Nystatin)

Nystatin is used to treat fungal infections of the vaginal mucosa, primarily targeting Candida species.

• Vaginal candidiasis: eliminates Candida overgrowth, relieving itching, discharge, and irritation.
• Recurrent vulvovaginal candidiasis: helps prevent repeated episodes when used as prescribed.

• Nystatin binds to ergosterol, a key sterol component of fungal cell membranes. This interaction creates pores that increase membrane permeability, causing leakage of intracellular electrolytes and macromolecules. The resulting loss of cellular integrity leads to fungal cell death, while human cells, which lack ergosterol, remain largely unaffected.

Common Side Effects

• Local irritation or burning sensation.
• Vaginal itching or mild discomfort.
• Increased vaginal discharge.
• Unpleasant odor at the application site.
• Mild allergic skin reaction.
• Temporary discoloration of vaginal secretions.

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis).
• Extensive vaginal ulceration.
• Persistent or worsening irritation.
• Systemic hypersensitivity manifestations.
• Rare cases of secondary bacterial infection.

Before using Nystatyna Vp, consider the following precautions:

• Assess for known hypersensitivity: avoid if the patient has a previous reaction to polyene antifungals.
• Avoid use in patients with extensive mucosal lesions: increased systemic absorption may occur.
• Do not use concurrently with vaginal douches, spermicides, or other products that may interfere with drug contact.
• Inform patients that the full prescribed treatment course should be completed, even if symptoms improve.
• Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Nystatyna Vp may interact with other agents as follows:

Major Interactions (Avoid)

• Concurrent systemic antifungals that share the same target may increase toxicity; avoid simultaneous use.

Moderate Interactions (Monitor Closely)

• Use with topical antibiotics may alter vaginal flora; monitor for secondary infections.
• Use with hormonal contraceptives has no known direct interaction, but monitor efficacy as vaginal irritation could affect absorption.
• Use with spermicides may reduce antifungal effectiveness; monitor clinical response.