Nystimex (Nystatin)

Nystatin is used to treat fungal infections that affect the skin and mucous membranes. It is effective in:

• Oral thrush: Reduces Candida overgrowth in the mouth, relieving soreness and white plaques.
• Esophageal candidiasis: Controls fungal growth in the esophagus, improving swallowing and reducing pain.
• Cutaneous candidiasis: Treats skin infections caused by Candida, easing redness, itching and irritation.
• Diaper rash: Alleviates fungal‑related diaper dermatitis in infants.
• Vaginal candidiasis: Helps clear yeast infection symptoms such as itching, discharge and irritation.

• Nystatin binds to ergosterol, a key component of fungal cell membranes, creating pores that increase membrane permeability. This leads to leakage of intracellular electrolytes and macromolecules, ultimately causing fungal cell death without affecting human cells that lack ergosterol.

Nystatin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

• Burning sensation
• Itching
• Redness
• Stinging
• Mild gastrointestinal upset
• Local irritation

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis)
• Significant skin blistering
• Persistent vomiting
• Widespread rash
• Swelling of the face or throat
• Unexplained fever

Before using Nystatin, consider several important safety measures:

• Assess risk of allergy to nystatin or formulation components: review patient history for previous reactions.
• Monitor renal function in patients with renal impairment to ensure appropriate use.
• Avoid use in patients with known hypersensitivity to poly‑poly poly fung fung .
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