Nyvigan (Nystatin)

Nystatin is a polyene antifungal used to treat infections caused by Candida species.

• Cutaneous candidiasis: reduces fungal load and resolves skin lesions.
• Vaginal candidiasis: alleviates itching, discharge and inflammation.

• Nystatin binds selectively to ergosterol, a key sterol in fungal cell membranes. This binding creates pores that increase membrane permeability, leading to leakage of intracellular components and ultimately causing fungal cell death while sparing human cells that lack ergosterol.

Adverse reactions may occur with topical or vaginal application of Nystatin.

Common Side Effects

• Local irritation or burning sensation at the application site.
• Itching or mild pruritus.
• Redness or erythema.
• Dryness or peeling of the skin or mucosa.
• Mild discomfort or stinging.
• Slight swelling of the treated area.

Serious or Rare Side Effects

• Allergic reaction such as rash, hives, or angioedema.
• Severe skin eruption or contact dermatitis.
• Swelling of the face, lips, or tongue.
• Difficulty breathing or wheezing.
• Systemic hypersensitivity symptoms.
• Unexplained fever or chills.

Before using Nyvigan, consider the following safety measures.

• Allergy assessment: avoid if known hypersensitivity to nystatin or other polyene antifungals.
• Pregnancy: consult a healthcare provider; safety has not been established.
• Breastfeeding: discuss potential risks with a physician before use.
• Application site: do not apply to extensive broken skin unless directed by a clinician.
• Concurrent antifungal therapy: inform the prescriber of any other topical or systemic antifungal agents.
• Store at room temperature: keep in the original container, protect from moisture and direct light.

Nystatin may interact with other medications or substances applied to the same area.

Major Interactions (Avoid)

• Concurrent use of other topical antifungal agents may increase local irritation.
• Use with topical corticosteroids without medical advice may reduce antifungal efficacy.

Moderate Interactions (Monitor Closely)

• Systemic antibiotics can alter normal flora, potentially increasing the risk of secondary infections.
• Use with occlusive dressings may enhance absorption and increase irritation risk.
• Co‑administration with other vaginal products should be spaced to avoid dilution of effect.