Nyvigan (Nystatin)

Nystatin is used to treat superficial fungal infections caused by Candida species.

• Oral thrush (candidiasis): reduces fungal colonization in the mouth and alleviates symptoms.
• Esophageal candidiasis: treats infection of the esophagus and promotes healing.
• Dermatophytic infections (e.g., diaper rash, intertrigo): alleviates cutaneous Candida infection and relieves irritation.
• Vaginal candidiasis: provides topical antifungal action to clear infection and reduce discharge.

• Nystatin binds selectively to ergosterol in the fungal cell membrane, forming pores that increase membrane permeability. This leads to leakage of essential intracellular ions and molecules, causing rapid fungal cell death. Because it is poorly absorbed through intact skin or mucosa, its action remains largely localized to the site of application.

Common Side Effects

• Local irritation: mild redness or itching at the application site.
• Burning sensation: transient discomfort when applied to mucous membranes.
• Nausea: occasional when used in the oral cavity.
• Diarrhea: rare gastrointestinal upset if swallowed in large amounts.

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis): swelling, difficulty breathing, or hives.
• Systemic toxicity: rare but possible with extensive absorption.
• Liver enzyme elevation: uncommon, monitor if prolonged use.
• Contact dermatitis: persistent skin rash at the site of application.

Before using Nyvigan, consider the following precautions:

• Allergy assessment: avoid if known hypersensitivity to polyene antifungals.
• Pregnancy: use only if clearly needed and after medical consultation.
• Breastfeeding: caution advised; discuss with a healthcare professional.
• Renal impairment: monitor as Nystatin is minimally absorbed but may accumulate.
• Drug interactions: review concomitant medications for potential effects.
• Store at ambient temperature: keep in original container, protect from moisture and light.

Nystatin may interact with other agents as follows:

Major Interactions (Avoid)

• Systemic antifungals (e.g., amphotericin B): concurrent use may increase toxicity.
• Nephrotoxic drugs: avoid high‑dose combined therapy due to potential renal stress.

Moderate Interactions (Monitor Closely)

• Antacids: may reduce oral absorption of Nystatin.
• Probiotics: could alter gut flora when large amounts are swallowed.
• Broad‑spectrum antibiotics: may predispose to fungal overgrowth, requiring closer observation.