Product image of Oasil (Chlordiazepoxide Hydrochloride) supplied by GNH India

Oasil

Active Ingredient:
Chlordiazepoxide Hydrochloride
Origin:
EU

Oasil (Chlordiazepoxide Hydrochloride)

Chlordiazepoxide, the active ingredient in Oasil, is a benzodiazepine presented as an oral dosage form for oral use. It treats anxiety disorders, helps manage acute alcohol withdrawal, and provides sedation before medical procedures in adult patients.
GNH India supplies Oasil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gap S.A.

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Indications & Clinical Uses

Chlordiazepoxide is a benzodiazepine that acts on the central nervous system to relieve anxiety‑related conditions and facilitate sedation.

  • Anxiety disorders: reduces excessive worry and tension in patients with generalized anxiety.
  • Acute alcohol withdrawal: alleviates tremor, agitation, and risk of seizures during early detoxification.
  • Sedation before medical procedures: provides calming and amnestic effects for minor surgeries or diagnostic tests.

How It Works

  • Chlordiazepoxide acts as a positive allosteric modulator of the GABA‑A receptor complex, binding to the benzodiazepine site and enhancing the inhibitory effect of the neurotransmitter GABA. This increased chloride ion influx hyperpolarizes neuronal membranes, leading to reduced neuronal excitability and producing anxiolytic, sedative, and muscle‑relaxant effects in the central nervous system.

Side Effects

Chlordiazepoxide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Drowsiness
  • Dizziness
  • Fatigue
  • Blurred vision
  • Impaired coordination
  • Short‑term memory impairment

Serious or Rare Side Effects

  • Respiratory depression
  • Severe hypotension
  • Paradoxical agitation or aggression
  • Physical dependence and withdrawal syndrome
  • Seizures upon abrupt discontinuation
  • Hepatic dysfunction or jaundice

Precautions & Warnings

Before prescribing chlordiazepoxide, clinicians should consider several safety factors.

  • Evaluate respiratory status: patients with COPD or sleep apnea may be at increased risk.
  • Review hepatic function: impaired metabolism can raise drug concentrations.
  • Assess for substance dependence: risk of tolerance and dependence with prolonged use.
  • Use caution in elderly: heightened sensitivity to sedative effects.
  • Avoid concurrent CNS depressants: may potentiate sedation and respiratory depression.
  • Store at room temperature: keep below 25°C in original container, protect from moisture.

Avoid Interactions

Chlordiazepoxide can interact with other medications, altering its efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: additive CNS depression and increased sedation.
  • Opioids: heightened risk of respiratory depression and profound sedation.
  • Barbiturates: synergistic depressant effects on the central nervous system.
  • Other benzodiazepines: excessive sedation and cumulative respiratory depression.
  • Antihistamines: increased drowsiness and impaired psychomotor performance.
  • CNS depressants: amplified sedative and respiratory effects.

Moderate Interactions (Monitor Closely)

  • SSRIs and other antidepressants: may increase sedation.
  • Anticonvulsants (e.g., carbamazepine): can alter chlordiazepoxide metabolism.
  • CYP3A4 inhibitors (e.g., erythromycin): may raise plasma levels.
  • CYP3A4 inducers (e.g., rifampin): may reduce effectiveness.
  • Oral contraceptives: potential for altered hormone levels.

Frequently Asked Questions

Oasil contains chlordiazepoxide, a benzodiazepine indicated for the short‑term relief of anxiety disorders, management of acute alcohol withdrawal symptoms, and as a pre‑procedural sedative to calm patients before minor medical or diagnostic procedures.

Chlordiazepoxide enhances the activity of the neurotransmitter GABA at the GABA‑A receptor complex, increasing chloride ion flow into neurons. This hyperpolarizes the cells, reducing neuronal firing and producing anxiolytic, sedative, and muscle‑relaxant effects.

The appropriate dose of Oasil is determined by the prescribing clinician based on the patient’s condition, age, liver function, and response to therapy. Dosage adjustments may be needed for the elderly or those with hepatic impairment.

Chlordiazepoxide is classified as Pregnancy Category D, indicating evidence of risk to the fetus. It is generally avoided during pregnancy and lactation unless the potential benefit justifies the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the Oasil product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Oasil (chlordiazepoxide) is an older, long‑acting benzodiazepine with a slower onset compared with agents like lorazepam or alprazolam. Its prolonged half‑life can be advantageous for managing alcohol withdrawal but may increase daytime sedation, making it less suitable for acute anxiety where a shorter‑acting agent is preferred.

Oasil should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not store in humid or excessively hot environments.

Oasil is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include respiratory depression, especially when combined with other CNS depressants, severe hypotension, paradoxical agitation, dependence, and withdrawal seizures if the medication is stopped abruptly after prolonged use.

Patients with severe respiratory insufficiency, acute narrow‑angle glaucoma, known hypersensitivity to chlordiazepoxide or other benzodiazepines, and those with a history of severe substance dependence should avoid Oasil. It is also contraindicated in individuals taking certain interacting medications without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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