Product image of Obimal (Otilonium Bromide) supplied by GNH India

Obimal

Active Ingredient:
Otilonium Bromide
Origin:
EU

Obimal (Otilonium Bromide)

Otilonium bromide, the active ingredient in Obimal, is an antispasmodic (spasmolytic) presented as an oral formulation for oral use. It is used to relieve gastrointestinal smooth‑muscle spasms in conditions such as irritable bowel syndrome, abdominal pain and intestinal colic.

GNH India supplies Obimal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Malesci Istituto Farmacobiologico - S.P.A.

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Indications & Clinical Uses

Obimal, an antispasmodic acting on gastrointestinal smooth muscle, is indicated for several functional bowel disorders.

  • Irritable bowel syndrome: reduces abdominal cramping and improves bowel habit regularity.
  • Abdominal pain: alleviates pain caused by intestinal spasm.
  • Intestinal colic: eases severe, episodic abdominal discomfort associated with colic.

How It Works

  • Otilonium bromide blocks calcium channels and exhibits antimuscarinic activity in the gastrointestinal tract, leading to reduced intracellular calcium influx and decreased smooth‑muscle contractility. This dual action diminishes the frequency and intensity of spasms, providing symptomatic relief in functional bowel disorders.

Side Effects

Adverse reactions may occur with any antispasmodic therapy.

Common Side Effects

  • Dry mouth: reduced salivary secretion.
  • Constipation: slowed intestinal transit.
  • Nausea: mild gastrointestinal upset.
  • Dizziness: transient light‑headedness.
  • Headache: mild to moderate intensity.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Severe hypotension: marked drop in blood pressure.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Hepatic dysfunction: elevated liver enzymes.
  • Pancreatitis: abdominal pain with elevated enzymes.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Pregnancy: consult a healthcare professional; safety data are limited.
  • Breastfeeding: evaluate risk versus benefit with a clinician.
  • Hepatic impairment: use with caution; monitor liver function.
  • Renal impairment: adjust use if necessary; monitor renal parameters.
  • Concomitant anticholinergics: may increase antimuscarinic effects.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Otilonium bromide may interact with other medications; awareness of interaction severity is important.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: may increase systemic exposure.
  • Other anticholinergic agents: risk of additive antimuscarinic effects.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: possible additive blood pressure lowering.
  • Diuretics: monitor electrolyte balance.
  • Antidepressants with anticholinergic properties: watch for enhanced side effects.

Frequently Asked Questions

Obimal contains otilonium bromide and is prescribed to manage functional gastrointestinal disorders such as irritable bowel syndrome, abdominal pain caused by intestinal spasms, and episodes of intestinal colic. It helps reduce muscle contractions and associated discomfort in the digestive tract.

Otilonium bromide acts as a calcium‑channel blocker and has antimuscarinic activity. By inhibiting calcium entry into smooth‑muscle cells and blocking muscarinic receptors, it lowers the contractile activity of gastrointestinal muscles, thereby relieving spasms and related pain.

The specific dosage of Obimal is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and overall health status. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for otilonium bromide in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against possible risks before prescribing Obimal to pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Obimal’s active ingredient, otilonium bromide, combines calcium‑channel blockade with antimuscarinic effects, offering a dual mechanism that may provide more consistent relief of gastrointestinal spasms compared with agents that act solely on one pathway, such as hyoscine or dicyclomine.

Obimal should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Obimal is taken orally, usually with a glass of water. The exact timing relative to meals and frequency should follow the prescribing clinician’s directions, which are tailored to the individual’s therapeutic needs.

Serious adverse reactions, though rare, can include allergic responses such as rash or anaphylaxis, severe hypotension, cardiac arrhythmias, hepatic dysfunction, and pancreatitis. Patients should seek immediate medical attention if they experience any of these symptoms.

Obimal should be avoided in individuals with known hypersensitivity to otilonium bromide or any excipients, and caution is advised for patients with severe hepatic or renal impairment, uncontrolled cardiovascular disease, or those taking medications that may cause dangerous additive anticholinergic effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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