Product image of Octaplasmalg (B) (Human Plasma Protein) supplied by GNH India

Octaplasmalg (B)

Active Ingredient:
Human Plasma Protein
Origin:
EU

Octaplasmalg (B) (Human Plasma Protein)

Human plasma protein, the active ingredient in Octaplasmalg (B), is a plasma protein (solvent/detergent‑treated plasma) presented as a solution for injection for intravenous use. It is used to replace coagulation factors and plasma proteins in patients with bleeding disorders, massive hemorrhage, or plasma protein deficiencies.

GNH India supplies Octaplasmalg (B) as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Octapharma S.A.

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Indications & Clinical Uses

Octaplasmalg (B) provides plasma protein support for disorders of coagulation and plasma volume.

  • Replacement therapy for coagulation factor deficiencies: restores missing clotting factors to achieve hemostasis.
  • Management of massive hemorrhage or massive transfusion protocols: supplies a broad spectrum of factors to control bleeding.
  • Correction of plasma protein deficiencies (e.g., hypoalbuminemia): replenishes albumin and other proteins to improve oncotic pressure.
  • Reversal of anticoagulation (e.g., warfarin) when rapid plasma replacement is needed: supplies functional clotting factors to counteract anticoagulant effect.
  • Support in liver disease or surgical settings requiring plasma protein supplementation: provides necessary proteins for coagulation and volume maintenance.

How It Works

  • Octaplasmalg (B) delivers a solvent/detergent‑treated plasma matrix that contains a full complement of coagulation factors, albumin, and other plasma proteins. By expanding plasma volume and supplying functional clotting factors, it restores the intrinsic and extrinsic pathways of coagulation, promotes platelet adhesion, and helps re‑establish hemostasis in patients with deficient or depleted plasma components.

Side Effects

Adverse reactions may occur with any plasma‑derived product and should be monitored during and after infusion.

Common Side Effects

  • Fever or chills
  • Mild hypotension
  • Headache
  • Transfusion‑associated circulatory overload (TACO)
  • Mild allergic rash or urticaria
  • Nausea

Serious or Rare Side Effects

  • Anaphylaxis or severe allergic reaction
  • Transfusion‑related acute lung injury (TRALI)
  • Severe hypotension or shock
  • Hemolytic transfusion reaction
  • Viral transmission (rare due to donor screening)
  • Disseminated intravascular coagulation (DIC) in susceptible patients

Precautions & Warnings

Use of Octaplasmalg (B) requires careful clinical assessment and monitoring.

  • Verify compatibility: confirm blood type and perform cross‑match before infusion.
  • Monitor volume status: avoid fluid overload in patients with cardiac or renal impairment.
  • Assess infection risk: ensure donor screening and product testing have been completed.
  • Observe for allergic reactions: have emergency medications ready to treat anaphylaxis.
  • Use aseptic technique: maintain sterility during preparation and administration.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Octaplasmalg (B) may interact with other therapies that affect coagulation or fluid balance.

Major Interactions (Avoid)

  • Concurrent plasma products: may cause volume overload.
  • High‑dose anticoagulants: can diminish the intended hemostatic effect.
  • Fibrinolytic agents: increase risk of uncontrolled bleeding.

Moderate Interactions (Monitor Closely)

  • Diuretics: may alter fluid balance; monitor electrolytes.
  • Immunosuppressants: heightened infection risk; observe for signs of infection.
  • Other blood components (e.g., red cells, platelets): monitor for additive volume and electrolyte shifts.

Frequently Asked Questions

Octaplasmalg (B) is a solvent/detergent‑treated plasma product used to replace missing or depleted coagulation factors and plasma proteins. It is indicated for patients with coagulation factor deficiencies, massive hemorrhage, hypoalbuminemia, reversal of anticoagulation, and situations where rapid plasma volume expansion is required, such as major surgery or liver disease.

Human plasma protein in Octaplasmalg (B) provides a broad spectrum of functional clotting factors, albumin, and other plasma proteins. By restoring these components, the product re‑activates the intrinsic and extrinsic coagulation pathways, improves oncotic pressure, and supports overall hemostasis, helping the body to stop bleeding and maintain circulatory stability.

The dose of Octaplasmalg (B) is individualized and determined by the prescribing clinician based on the patient’s weight, severity of bleeding, laboratory values, and clinical situation. Healthcare professionals calculate the required volume to achieve target coagulation factor levels and plasma volume replacement.

Safety data for Octaplasmalg (B) in pregnancy and lactation are limited. The product should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by the treating physician in consultation with obstetric specialists.

To order Octaplasmalg (B), submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed), and any required import documentation.

Octaplasmalg (B) is a solvent/detergent‑treated plasma product, offering a standardized, pathogen‑reduced alternative to fresh frozen plasma (FFP). It provides consistent clotting factor levels, a longer shelf‑life, and reduced risk of viral transmission, while still delivering the same broad spectrum of plasma proteins needed for hemostasis.

Octaplasmalg (B) must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking. Before use, allow the product to reach room temperature if required by the administration protocol, and inspect for any discoloration or particulate matter.

Octaplasmalg (B) is administered intravenously. The solution is infused through a dedicated IV line, typically using a controlled infusion pump or gravity drip, according to the prescriber’s instructions. Vital signs and coagulation parameters are monitored throughout the infusion to ensure safety and efficacy.

Serious risks include severe allergic reactions such as anaphylaxis, transfusion‑related acute lung injury (TRALI), severe hypotension or shock, hemolytic transfusion reactions, and the rare possibility of viral transmission despite donor screening. Immediate medical intervention is required if any of these events occur.

Octaplasmalg (B) should be avoided in patients with known hypersensitivity to human plasma proteins, a history of severe transfusion reactions, or those who have received incompatible plasma. Caution is also advised for individuals with uncontrolled heart failure, severe renal impairment, or active disseminated intravascular coagulation, where volume overload could be hazardous.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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