Octenisept (Octenidine Dihydrochloride, Phenoxyethanol)

• Octenisept is an antiseptic that reduces microbial load on skin and mucosal surfaces.
• Skin antisepsis: Reduces bacterial colonisation on intact or abraded skin prior to invasive procedures.
• Wound cleansing: Helps cleanse superficial wounds and minor injuries to prevent infection.
• Vaginal antisepsis: Provides antimicrobial action for vaginal preparations before gynecological procedures.
• Preoperative skin preparation: Used to prepare the surgical site, lowering the risk of postoperative infection.

• Octenidine dihydrochloride disrupts bacterial cell membrane integrity, causing rapid leakage of intracellular contents and cell death. Phenoxyethanol contributes to membrane destabilisation and acts as a preservative, enhancing the overall antimicrobial effect. The combination provides broad‑spectrum activity against Gram‑positive and Gram‑negative bacteria, fungi and some enveloped viruses, making it effective for topical antisepsis.

Octenisept is generally well tolerated, but local reactions can occur.

Common Side Effects

• Mild skin irritation or erythema at the application site.
• Transient itching or burning sensation.
• Temporary pain or discomfort during application.
• Allergic contact dermatitis in sensitised individuals.

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis) requiring immediate medical attention.
• Extensive ulceration or necrosis if applied to large open wounds.
• Persistent swelling or blistering indicating a severe local reaction.

• Use Octenisept according to professional guidance and observe the following precautions.
• Avoid use on extensive open wounds: limit application to superficial lesions only.
• Do not apply to mucous membranes other than the vagina: avoid eyes, ears and oral cavity.
• Check for hypersensitivity before first use: perform a small test area.
• Use only as directed by a healthcare professional: follow recommended frequency and amount.
• Store at room temperature: keep container tightly closed, protect from light and moisture.

Octenisept may interact with other topical agents; consider the following.

Major Interactions (Avoid)

• Concurrent use with other antiseptic solutions containing chlorhexidine: may increase irritation.
• Application over dressings containing silver or iodine: can cause chemical incompatibility.

Moderate Interactions (Monitor Closely)

• Use with topical corticosteroids: may reduce antiseptic efficacy.
• Combination with wound healing gels: monitor for increased local irritation.
• Application before adhesive bandages: ensure skin is dry to avoid adhesive failure.